Sophora/Ku shen

by alienherbalist | Posted on

 

Sophora/Ku shen

 

Sophora/Ku shen is a chinese herb that appears to help against tachycardia, cancer, viral & bacterial infections, erectile dysfunction, edema, inflammation, ulcerative colitus & promote hair growth (topically).

 

References from  mskcc.org/cancer-care/integrative-medicine/herbs/sophora-flavescens

 

  1. Chen JK and Chen TT. Chinese Medical Herbology and Pharmacology. First ed. 2004, City of Industry, CA: Art of Medicine Press, Inc.
  2. Jiang H, Hou C, Zhang S, et al. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J Pharmacol. 2007 Mar 22;559(2-3):98-108.
  3. Liu XS, et al. Matrine-induced apoptosis in leukemia U937 cells: involvement of caspases activation and MAPK-independent pathways. Planta Med. 2006;2(6): 501-6.
  4. Piao XL, et al. Identification and characterization of antioxidants from Sophora flavescens. Biol Pharm Bull. 2006;9(9): 1911-5.
  5. Hoang BX, et al. New approach in asthma treatment using excitatory modulator. Phytotherapy Res. 2007;21(6): p. 554-7.
  6. Chen C, et al. A randomized controlled trial of kurorinone versus interferon-alpha2a treatment in patients with chronic hepatitis B. J Viral Hepat. 2000;7(3): p. 225-9.
  7. Chen SX, et al. [Therapeutic effect of kangke injection on viral myocarditis and its anticoxsackie virus mechanism]. Zhong Guo Zhong Xi Yi Jie He Za Zhi. 1997. 17(4): p. 207-9.
  8. Liu Z, et al. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine. 2008;15(10):867-75.
  9. Lee JH, et al. A new cytotoxic prenylated chalcone from Sophora flavescens. Arch Pharm Res. 2007;30(4): 408-11.
  10. Ma L, et al., Anticancer effects of the chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008;74(3): 245-51.
  11. Zhang Y, et al. Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats. Life Sci. 2006; 78(17):1998-2005.
  12. Yamahara J, et al. Vasodilatory active principles of Sophora flavescens root.J Ethnopharmacol. 1990;29(1): p. 79-85.
  13. Kim DW, et al. Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch Pharm Res. 2002;25(3): 329-35.
  14. Zhang L, et al. Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2008;47(4-5): 892-898.
  15.  Xiang Q, et al. [Anti-leukemia effect of Sophora flavescens combined with the low molecular weight natural tumor suppressor of the human fetal liver and its mechanism]. Hunan Yi Ke Da Xue Xue Bao. 2002;27(2): 108-10.
  16. Sun M, et al. Novel antitumor activities of Kushen flavonoids in vitro and in vivo. Phytother Res. 2007;21(3): 269-77.
  17. Cha JD, et al. Antibacterial activity of sophoraflavanone G isolated from the roots of Sophora flavescens. J Microbiol Biotechnol. 2007;17(5): 858-64.
  18. Yu HB, Zhang HF, Li DY, et al. Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. J Asian Nat Prod Res. 2011 Mar;13(3):242-50.
  19. Li H, Tan G, Jiang X, et al. Therapeutic effects of matrine on primary and metastatic breast cancer. Am J Chin Med. 2010;38(6):1115-30.
  20. Liu T, Song Y, Chen H, Pan S, Sun X. Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo. Biol Pharm Bull. 2010;33(10):1740-5.
  21. Han Y, Zhang S, Wu J, et al. Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway. Leuk Lymphoma. 2010 Jul;51(7):1337-46.
  22. Dai ZJ, Gao J, Ji ZZ, et al. Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3. J Ethnopharmacol. 2009 May 4;123(1):91-6.
  23. Jiang T, Zhu Y, Luo C, et al. Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells. Planta Med. 2007 Sep;73(11):1176-81.
  24. Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res. 2006 Nov;20(11):1017-9.
  25. De Naeyer A, Vanden Berghe W, Pocock V, et al. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. J Nat Prod. 2004 Nov;67(11):1829-32.
  26. Yoo HH, Kim T, Ahn S, et al. Evaluation of the estrogenic activity of Leguminosae plants. Biol Pharm Bull. 2005 Mar;28(3):538-40.
  27. Choi SU, Kim KH, Choi EJ, et al. P-glycoprotein (Pgp) does not affect the cytotoxicity of flavonoids from Sophora flavescens, which also have no effects on Pgp action. Anticancer Res. 1999 May-Jun;19(3A):2035-40.
  28. Shen CC, Lin TW, Huang YL, et al. Phenolic constituents of the roots of Sophora flavescens. J Nat Prod. 2006 Aug;69(8):1237-40.
  29. Kim JY, Kim JY, Kim JJ, et al. (2S)-2’-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling. Biol Pharm Bull. 2014;37(2):255-61.
  30. Yu Q, Cheng N, Ni X. Identifying 2 prenylflavanones as potential hepatotoxic compounds in the ethanol extract of Sophora flavescens. J Food Sci. 2013 Nov;78(11):T1830-4.
  31. Chen M, Ding Y, Tong Z. Efficacy and Safety of Sophora flavescens (Kushen) Based Traditional Chinese Medicine in the Treatment of Ulcerative Colitis: Clinical Evidence and Potential Mechanisms. Front Pharmacol. 2020 Dec 10;11:603476.
  32. Hou WB, Sun WJ, Zhang XW, et al. Five-Flavor Sophora flavescens Enteric-Coated Capsules for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Evid Based Complement Alternat Med. 2022 Jan 12;2022:9633048.
  33. Yu ZY, Peng RY, Han M, et al. Adjunctive effect of compound Kushen Injection to chemotherapy for non-small cell lung cancer: An evidence map and overview of systematic reviews. J Ethnopharmacol. 2021 Dec 5;281:114538.

 

References from examine.com/supplements/ku-shen/research/#p2p8j27-sources-and-composition

1.^Sun M, Cao H, Sun L, Dong S, Bian Y, Han J, Zhang L, Ren S, Hu Y, Liu C, Xu L, Liu PAntitumor activities of kushen: literature reviewEvid Based Complement Alternat Med.(2012)
4.^Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi TAntibacterial and antiandrogen flavonoids from Sophora flavescensJ Nat Prod.(1999 Dec)
5.^Berghe WV, De Naeyer A, Dijsselbloem N, David JP, De Keukeleire D, Haegeman GAttenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. rootsEndocr Metab Immune Disord Drug Targets.(2011 Sep 1)
6.^Shin HJ, Kim HJ, Kwak JH, Chun HO, Kim JH, Park H, Kim DH, Lee YSA prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5Bioorg Med Chem Lett.(2002 Sep 2)
8.^Zhang JH, Zhao YY, Liu QX, Ye XJStudies on the chemical constituents from Sophora flavescens aitZhongguo Zhong Yao Za Zhi.(2000 Jan)
9.^Woo ER, Kwak JH, Kim HJ, Park HA new prenylated flavonol from the roots of Sophora flavescensJ Nat Prod.(1998 Dec)
11.^Bai L, Zhu LY, Yang BS, Shi LJ, Liu Y, Jiang AM, Zhao LL, Song G, Liu TFAntitumor and immunomodulating activity of a polysaccharide from Sophora flavescens AitInt J Biol Macromol.(2012 Dec)
18.^Xie MZ, Zhou WZ, Zhang YOxymatrine metabolic fateChin Med J (Engl).(1983 Feb)
22.^Cui L, Zhang X, Yang R, Wang L, Liu L, Li M, Du WNeuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of ratsNeurol Res.(2011 Apr)
23.^Fan H, Li L, Zhang X, Liu Y, Yang C, Yang Y, Yin JOxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemiaMediators Inflamm.(2009)
24.^Huang M, Hu YY, Dong XQ, Xu QP, Yu WH, Zhang ZYThe protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brainJ Ethnopharmacol.(2012 Aug 30)
25.^Zhang K, Li YJ, Yang Q, Gerile O, Yang L, Li XB, Guo YY, Zhang N, Feng B, Liu SB, Zhao MGNeuroprotective effects of oxymatrine against excitotoxicity partially through down-regulation of NR2B-containing NMDA receptorsPhytomedicine.(2012 Dec 5)
27.^Zhou XH, Wei X, Huang ZS, Cen C, Yin YX, Qin YQ, Su QBEffects of matrine on proliferation and telomerase activity of colon cancer SW1116 cellsZhong Yao Cai.(2009 Jun)
29.^Jung HA, Moon HE, Oh SH, Kim BW, Sohn HS, Choi JSKinetics and molecular docking studies of kaempferol and its prenylated derivatives as aldose reductase inhibitorsChem Biol Interact.(2012 May 30)
30.^Quang TH, Ngan NT, Minh CV, Kiem PV, Tai BH, Nhiem NX, Thao NP, Luyen BT, Yang SY, Kim YHAnti-Inflammatory and PPAR Transactivational Properties of Flavonoids from the Roots of Sophora flavescensPhytother Res.(2012 Oct 30)
31.^Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang GMatrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signalingCytotechnology.(2009 Apr)
32.^Li LQ, Li XL, Wang L, Du WJ, Guo R, Liang HH, Liu X, Liang DS, Lu YJ, Shan HL, Jiang HCMatrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cellsCell Physiol Biochem.(2012)
33.^Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang GEffects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migrationCytotechnology.(2009 Apr)
35.^Zhang J, Li Y, Chen X, Liu T, Chen Y, He W, Zhang Q, Liu SAutophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cellsOncol Rep.(2011 Jul)
36.^Dai ZJ, Gao J, Ji ZZ, Wang XJ, Ren HT, Liu XX, Wu WY, Kang HF, Guan HTMatrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3J Ethnopharmacol.(2009 May 4)
37.^Zhang S, Zhang Y, Zhuang Y, Wang J, Ye J, Zhang S, Wu J, Yu K, Han YMatrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt InactivationPLoS One.(2012)
38.^Zhang JQ, Li YM, Liu T, He WT, Chen YT, Chen XH, Li X, Zhou WC, Yi JF, Ren ZJAntitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagyWorld J Gastroenterol.(2010 Sep 14)
40.^Chen K, Hu Z, Wang T, Guo H, Ye ZInhibitory effect of matrine on the expression of PSA and AR in prostate cancer cell line LNCaPJ Huazhong Univ Sci Technolog Med Sci.(2008 Dec)
41.^Chen K, Hu ZQ, Wang T, Guo JL, Guo H, Ye ZQMatrine inhibits the proliferation of prostate cancer cells and the activity of androgen receptorZhonghua Nan Ke Xue.(2008 Aug)
43.^Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, Cheng X, Qian R, Zhang XMatrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cellsEur J Pharmacol.(2007 Mar 22)
44.^Liu XY, Fang H, Yang ZG, Wang XY, Ruan LM, Fang DR, Ding YG, Wang YN, Zhang Y, Jiang XL, Chen HCMatrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitroInt J Dermatol.(2008 May)
45.^Chen CH, Lai JM, Chou TY, Chen CY, Su LJ, Lee YC, Cheng TS, Hong YR, Chou CK, Whang-Peng J, Wu YC, Huang CYVEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathwayPLoS One.(2009)
46.^Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YKThe hair growth promoting effect of Sophora flavescens extract and its molecular regulationJ Dermatol Sci.(2002 Oct)
47.^Jung MJ, Kang SS, Jung HA, Kim GJ, Choi JSIsolation of flavonoids and a cerebroside from the stem bark of Albizzia julibrissinArch Pharm Res.(2004 Jun)
48.^Lee NK, Son KH, Chang HW, Kang SS, Park H, Heo MY, Kim HPPrenylated flavonoids as tyrosinase inhibitorsArch Pharm Res.(2004 Nov)
49.^Kim SJ, Son KH, Chang HW, Kang SS, Kim HPTyrosinase inhibitory prenylated flavonoids from Sophora flavescensBiol Pharm Bull.(2003 Sep)
50.^Son JK, Park JS, Kim JA, Kim Y, Chung SR, Lee SHPrenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activityPlanta Med.(2003 Jun)
51.^Ryu YB, Westwood IM, Kang NS, Kim HY, Kim JH, Moon YH, Park KHKurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescensPhytomedicine.(2008 Aug)
54.^Lin P, Zhang J, Rong Z, Han R, Xu S, Gao R, Ding Z, Wang J, Feng H, Cao SStudies on medicamentous inhibitory therapy for esophageal precancerous lesions–3- and 5-year inhibitory effects of antitumor-B, retinamide and riboflavinProc Chin Acad Med Sci Peking Union Med Coll.(1990)
55.^Zhang Z, Wang Y, Yao R, Li J, Yan Y, La Regina M, Lemon WL, Grubbs CJ, Lubet RA, You MCancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor modelsOncogene.(2004 May 6)
56.^Sit DS, Gao G, Law FC, Li PCGas chromatography-mass spectrometry determination of matrine in human plasmaJ Chromatogr B Analyt Technol Biomed Life Sci.(2004 Sep 5)

About the author

MD has worked through severe lifelong developmental disabilities (and a brain injury) with much more success than the medical press suggests is possible. He is motivated to share his research and personal experiences with everyone who wants it, and doesn't solicit payment.

Related Posts

Comments

  1. Pingback: Hair – AlienHerbalist.com

Comments are closed.