N-acetylcysteine(NAC)

 

N-acetylcysteine (NAC)

 

 

NAC is an amino acid that replenishes intracellular glutathione, which is lower as we age.

 

NAC also appears to help prevent & treat COPD, idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), emphysema, bronchitis, lower respiratory infections like the flu by stopping the virus & the inflammation, etc, especially as an inhalant.

 

NAC appears to help against stomach ulcers, kidney & liver damage & failure, acetominophen (Tylenol) overdose, endometriosis including fertility complications, & acetaminophen toxicity.

 

NAC appears to improve workout recovery & insulin sensitivity.

 

NAC appears to prevent & treat cancer at multiple stages in multiple ways.

 

NAC appears to help neuropathy & progressive myoclonic epilepsy.

 

NAC is an amino acid that appears to help schizophrenia, autism, Alzheimer’s, Parkinson’s, alcohol/cocaine/cannabis/nicotine relapse & cravings, gambling, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder.

 

Studies on COPD used 2.8 grams per day safely & effectively in two or three divided doses.

 

 

Biol Psychiatry. 2008 Sep 1;64(5):361-8. doi: 10.1016/j.biopsych.2008.03.004. Epub 2008 Apr 23.

N-acetyl cysteine as a glutathione precursor for schizophrenia–a double-blind, randomized, placebo-controlled trial.

Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Bush AI

J Psychiatry Neurosci. 2011 Mar; 36(2): 78–86.

doi:  10.1503/jpn.100057

PMCID: PMC3044191

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Olivia Dean et al.

 

Neuroscience & Biobehavioral Reviews

Volume 55, August 2015, Pages 294–321

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

Deepmala et al.

doi:10.1016/j.neubiorev.2015.04.015

Innov Clin Neurosci. 2011 Jan; 8(1): 10–14.

PMCID: PMC3036554

Getting a Knack for NAC

N-Acetyl-Cysteine

Randy A. Sansone and Lori A. Sansone

 

Depression-

 

Neuroscience & Biobehavioral Reviews

Volume 55, August 2015, Pages 294–321

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

Deepmala et al.

doi:10.1016/j.neubiorev.2015.04.015

 

flu nac

 

lifeextension.com/magazine/2010/5/N-Acetyl-Cysteine/Page-01

 

 addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder

J Psychiatry Neurosci. 2011 Mar; 36(2): 78–86.

doi:  10.1503/jpn.100057

PMCID: PMC3044191

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Olivia Dean et al.

 

schizophrenia, bipolar disorder) as well as psychiatric syndromes characterized by impulsive/compulsive symptoms (e.g., trichotillomania, pathological nail biting, gambling, substance misuse

 

Innov Clin Neurosci. 2011 Jan; 8(1): 10–14.

PMCID: PMC3036554

Getting a Knack for NAC

N-Acetyl-Cysteine

Randy A. Sansone and Lori A. Sansone

 

 

NAC appears to reduce contrast-induced acute kidney injury (CI-AKI).

 

Meta-analytic Techniques to Assess the Association Between N-acetylcysteine and Acute Kidney Injury After Contrast Administration: A Systematic Review and Meta-analysis

pubmed.ncbi.nlm.nih.gov/35788669

 

 

 

Drug addiction

 

 

NAC appears to reduce relapse from drug addiction

 

alienherbalist.com/cocainen

 

N-acetylcysteine (NAC) & alcohol addiction

 

 

NAC appears to reduce alcohol addiction relapse & overall alcohol intake by 30%, up to 60% when paired with aspirin.

 

N-acetylcysteine improves impulse control and attenuates relapse-like alcohol intake in long-term drinking rats
Ida Fredriksson, Nitya Jayaram-Lindström, Peter W. Kalivas, Philippe A. Melas, Pia Steensland,
Behavioural Brain Research, Volume 436, 2023, 114089, ISSN 0166-4328, https://doi.org/10.1016/j.bbr.2022.114089.
(https://www.sciencedirect.com/science/article/pii/S0166432822003576)

Squeglia LM, Tomko RL, Baker NL, McClure EA, Book GA, Gray KM. The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial. Drug Alcohol Depend. 2018 Apr 1;185:17-22. doi: 10.1016/j.drugalcdep.2017.12.005. Epub 2018 Feb 1. PMID: 29413434; PMCID: PMC5889716.

 

N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection

Front. Behav. Neurosci., 31 July 2020 Sec. Motivation and Reward V14-2020 doi.org/10.3389/fnbeh.2020.00122

 

liverdoctor.com/n-acetyl-cysteine-nac-may-offer-help-for-addictions/

 

 

N-acetylcysteine (NAC) & endometriosis

 

In one study of 97 women who had given up on hormonal treatment & were about to have surgery, 47 got 600mg of NAC 3X per day for 90 days.  24 cancelled the surgery (more than half), 8 had all their cysts disappear, 14 saw a drop in cysts, 21 had pain reductions, and one woman got pregnant during the trial, and another 8 soon after.  NAC has far fewer & milder side effects than hormonal treatment or surgery.

 

Evidence-Based Complementary and Alternative Medicine

Volume 2013 (2013), Article ID 240702, 7 pageshttp://dx.doi.org/10.1155/2013/240702

A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine

Maria Grazia Porpora et al.

 

 

 

 

About the author

MD has worked through severe lifelong developmental disabilities (and a brain injury) with much more success than the medical press suggests is possible. He is motivated to share his research and personal experiences with everyone who wants it, and doesn't solicit payment.