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Heart health
What may hurt:
Refined “vegetable oils”- heated polyunsaturated fats
High fructose corn syrup
Refined grains- white wheat flour, white rice
MNRA spike protein exposure or manufacture in the body
Commercial tobacco smoking products
PPIs & H2 blockers like omeprazole (used for reflux/GERD)
high iron levels
NSAIDs (except aspirin)
BPA in cans & plastics
hemodialysis
Prescription drugs that may hurt:
statins
Ezetimibe (Zetia)
fibrates
Noncentrally active ACE inhibitors-
benaza Lotensin
enala Vasotec
quina Accupril
Liphilic beta blockers:
metoprolol- anticholinergic
Non-selective β1/β2 beta blockers-
carteolol
carvedilol (Coreg) may also cause impotence
labetalol (Normodyne, Trandate)
nadolol (Corgard)
penbutolol (Levatol)
pindolol (Visken)
propranolol (Hemangeol, Inderal XL, InnoPran XL)
sotalol (Betapace, Sorine, Betapace AF)
timolol (Timoptic, Betimol, Timoptic-xe)
atenolol (Tenormin)- anticholinergic
Thiazide diuretics-
chlorothiazide (Diuril)
chlorthalidone (Hygroton)
methyclothiazide (Enduron)
metolazone (Zaroxolyn, Diulo, Mykrox)
hydrochlorothiazide (Hydrodiuril, Microzide)
Loop diuretics (also brain damage)-
torsemide (Demadex)
furosemide (Lasix)
bumetanide (Bumex)
ethacrynic acid (Edecrin)
Angiotensin-receptor blockers (ARBs)
olmesartan (Benicar)
ARBs + beta blockers + ACE inhibitors
ARBs + ACE inhibitors
Calcium channel blockers-
Nifedipine (Procardia)
Digoxin
Periodontal disease
Calcium channel blockers (especially with congestive heart failure)
Amlodipine (Norvasc)
Felodipine (Plendil)
Nicardipine (Cardene)
Diltiazem (Cardizem, Tiazac)
Isradipine
Nifedipine (Procardia) increases sun sensitivity & lip (and possibly skin) cancer
Nisoldipine (Sular)
Verapamil (Calan, Verelan, Covera-HS)
What may help in order of effectiveness:
Eating all organic (avoid hundreds of toxins in everyday food)
Cooking only with organic unrefined coconut oil, organic grass fed cow ghee, butter, lard (everything else has polyunsaturated fat turns into formaldehyde when heated)
Alpha lipoic acid 600mg at wakeup & before or after a meal per 200lbs for diabetes (1 month) & heart disease (4 months)
Daily sun exposure or vitamin D3- 1.25 mg (50K IU) 2x/week (if 200lbs) under the tongue (liquid, lozenge or pop open capsule) or swallowed with a fatty meal (fat soluble) & with a cup of dark leafy greens has magnesium, bioavailable calcium, zinc, boron, vitK1 we can make into vitK2 all essential to help vitamin D3 clean arteries of calcium & build bone.
Half a baby aspirin before bed, upon wakening in morning, & middle of day- more increases bleeding risk (if suspected heart attack or stroke then full aspirin under tongue/chewed).
Strophanthus (Ouabain) extract drops under tongue through day, when symptoms or during heart attack as recommended by European & American cardiologists (see Dr Thomas Cowan)
Brushing gums then teeth with a few drops of safer, concentrated dental iodine (like Iorinse) to stop hidden periodontal disease (3D cone xray may show)
Organic extra virgin olive oil from one country added before serving (no heating/cooking)
MCT oil (1/4ts-1ts every few hours or with every meal increases energy)
Hibiscus sabdariffa tea
Organic cocoa / dark chocolate or no sugar bakers chocolate melted with stevia, monk fruit, allulose, erithrytol or organic raw honey added
Probiotics with or at end of last meal of night
Organic frozen ground flaxseed
Magnesium- essential for heart & makes vitamin D3 5x more effective
Sustained release methyl vitamin B complex
Glucomannan fiber
Coffee
Vitamin K2 (if not gotten in organic natto or dark leafy green K1->K2)
Spirulina with a vegetable source of all DHA & EPA fish oil
Cordyceps mushroom
Medicinal mushroom mix
Hawthorn berry
Coenzyme Q/CoQ10/ubiquinol
L-carnitine- physical & cognitive energy & mood
Mulberry leaf extract
Organic celery
L-arginine- opens up arteries
L-Taurine
D-ribose
Betaine
Lecithin liposomal vitamin C
Sauna- every day of use increases longevity
Grounding
Peritoneal dialysis instead of hemodialysis significantly slows the progression of congestive heart failure
Peppers (unless autoimmune disease)
Turmeric w/black pepper
Organic brown rice instead of white rice
Olive leaf
Horse chestnut
Prescription drugs that may help-
Centrally active ACE inhibitors
fosinopril (Monopril)
ramipril (Altace)
trandolapril (Mavik)
perindopril (Aceon)
β1-selective beta blockers-
nebivolol (Bystolic) apparently safest by far, high dose for panic attacks & explosive disorder
acebutolol (Sectral)
betaxolol (Kerlone, Betoptic)
bisoprolol (Zebeta)
esmolol (Brevibloc)
Thiazide diuretic-
Indapamide (Lozol)
other thiazide diuretics may increase diabetes
Potassium-sparing diuretics-
triamterene (Dyrenium)
amiloride
eplerenone (Inspra)
spironolactone (Aldactone)
What may help a little:
Alpha-blockers
selective α1-adrenoceptor antagonists
prazosin
terazosin
trimazosin
doxazosin (Cardura) (may help benign prostatic hyperplasia, nightmares, and/or night terrors)
alfuzosin (Uroxatral)
tamsulosin (Flomax) (also may help enlarged prostate)
non-selective antagonists
phentolamine
phenoxybenzamine
Centrally acting α2-adrenoceptor agonists-clonidine Catapres- can change pupil dilation & dry eyes
guanabenz
guanfacine
α-methyldopa
Angiotensin-receptor blockers (ARBs)
iscandesartan (Atacand) may be the safest
telmisartan Micardis
irbesartan Avapro
losartan Cozaar g
eprosartan Teveten
valsartan Diovan (60% more effective if taken before bedtime)
Congestive heart failure, heart disease, blood pressure, heart attack, cholesterol, stroke
Congestive heart failure (CHF) & heart disease
Women & strokes
Risk factors
Lupus
Migraines
Oral contraception
Hormone replacement therapy
Pregnancy
Smoking
High blood pressure & smoking are risk factors for men as well.
OSU WMC, Columbus
Smoking and strokes
Women who smoke over 20 cigarettes a day had more than 800% more strokes in one study, while men had only 276% more.
Sex, Smoking, and Risk for Subarachnoid Hemorrhage
Joni Valdemar Lindbohm, Jaakko Kaprio, Pekka Jousilahti, Veikko Salomaa, Miikka Korja
https://doi.org/10.1161/STROKEAHA.116.012957
Stroke. 2016;STROKEAHA.116.012957
Stroke treatment
tPA treatment has a higher risk of hemorrhage than an aspirin under the toungue. What may cut stroke death risk almost in half with large clots is a thrombectomy with a stent-retriever to remove the clot up to 24 hours after the stroke. If the stroke patient is a candidate for thrombectomy a capable stroke center may be found at strokecenter.org/trials/centers.
Sameer Ansari, MD NM.org
JACC 2/26/18
Periodontal disease
Periodontal disease can invade the heart & appears to cause heart attack deaths, cancer, Alzheimer’s & other diseases by the amount of bacteria found post-mortem. Most periodontal disease appears to be from root canals & pulling teeth without pulling the ligament attached. These leave dead tissue & infection which is detectable with a 3D cone xray & treatable with ozone to kill bacteria & red laser to rebuild enamel or dental high elemental/molecular iodine (like Iorinse) with a few drops brushed on gums then teeth & a red coated chicken warming infrared light (like from Rural King for $6 & $9 safety cover clamp lamp) four minutes every eight hours at earliest.
Bisphenol A (BPA)
BPA is a chemical added to plastics and cans that affects hormones & other body systems. BPA exposure significantly appears to significantly raise blood pressure, angina, hypertension, heart attack, coronary and peripheral arterial disease, obesity, & diabetes & cause significant fetal, childhood, & adult developmental & reproductive problems.
Eating food from just one can lined with EPA raises blood levels 1000%.
JAMA. 2011 Nov 23;306(20):2218-20. doi: 10.1001/jama.2011.1721.
Canned soup consumption and urinary bisphenol A: a randomized crossover trial.
Carwile JL, Ye X, Zhou X, Calafat AM, Michels KB.
Heated plastics often leach chemicals even more toxic than BPA.
http://www.nytimes.com/2011/04/18/business/global/18iht-rbog-plastic-18.html
Environ Health. 2015 May 31;14:46. doi: 10.1186/s12940-015-0036-5.
Bisphenol A and the risk of cardiometabolic disorders: a systematic review with meta-analysis of the epidemiological evidence.
Reprod Toxicol. 2013 Dec;42:132-55. doi: 10.1016/j.reprotox.2013.08.008. Epub 2013 Aug 30.
Bisphenol A and human health: a review of the literature.
Int J Environ Res Public Health. 2014 Aug 15;11(8):8399-413. doi: 10.3390/ijerph110808399.
Impact of bisphenol a on the cardiovascular system – epidemiological and experimental evidence and molecular mechanisms.
Int J Mol Sci. 2012;13(8):10143-53. doi: 10.3390/ijms130810143. Epub 2012 Aug 15.
Epigenetic effects of environmental chemicals bisphenol A and phthalates.
Exposure to Bisphenol A From Drinking Canned Beverage Increases Blood Pressure
Sanghyuk Bae, Yun-Chul Hong
doi: 10.1161/HYPERTENSIONAHA.114.0426
Hypertension. 2012 Sep;60(3):786-93. doi: 10.1161/HYPERTENSIONAHA.112.197715. Epub 2012 Jul 30.
Associations of bisphenol A exposure with heart rate variability and blood pressure.
Bae S, Kim JH, Lim YH, Park HY, Hong YC.
Curr Hypertens Rep. 2016 Feb;18(2):11. doi: 10.1007/s11906-015-0617-2.
Bisphenol A, Hypertension, and Cardiovascular Diseases: Epidemiological, Laboratory, and Clinical Trial Evidence.
BPA exposure in cans raises blood pressure.
http://well.blogs.nytimes.com/2014/12/08/bpa-in-cans-and-plastic-bottles-linked-to-quick-rise-in-blood-pressure/?emc=edit_hh_20141209&nl=health&nlid=26219901
Testing
TMAO test- people with high levels of TMAO in one study had 600% more heart attacks or strokes in the next month than people with low levels.
Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
Xinmin S. Li et al.
European Heart Journal (2017) 0, 1–11
doi:10.1093/eurheartj/ehw582
Tachycardia
Thyroid
Having higher levels of free thyroxine (FT4), often indicative of hyperthyroidism, may double the rate of calcified coronary arteries and the risk of stroke & heart attack. Symptoms of hyperthyroidism may be weight loss, increased heart rate, insomnia, muscle weakness & anxiety.
Avoid BPA in metal cans
Hypertension. 2012 Sep;60(3):786-93. doi: 10.1161/HYPERTENSIONAHA.112.197715. Epub 2012 Jul 30.
Associations of bisphenol A exposure with heart rate variability and blood pressure.
Bae S, Kim JH, Lim YH, Park HY, Hong YC.
wikihow.com/Treat-Tachycardia-with-Home-Remedies
alienherbalist.com search Heart
Herbs
Hyperthyroidism
Having higher levels of free thyroxine (FT4), often indicative of hyperthyroidism, may double the rate of calcified coronary arteries and the risk of stroke & heart attack. Symptoms of hyperthyroidism may be weight loss, increased heart rate, insomnia, muscle weakness & anxiety.
Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study
Arjola Bano, Layal Chaker, Francesco U Mattace-Raso, Aad van der Lugt, M Arfan Ikram, Oscar H Franco, Robin P Peeters and Maryam Kavousi
Circulation Research. 2017;CIRCRESAHA.117.311603, originally published October 31, 2017
https://doi.org/10.1161/CIRCRESAHA.117.311603
BLP 39, 6 3/15/18 p1
Insulin & blood sugar drive heart disease
High insulin levels, which may rise for years before they result in high blood sugar, are the main cause of arterial plaque and vessel blockages. So using diabetes treatments should be the most effective against heart disease.
Atherosclerosis is a vascular stem cell disease caused by insulin
Traunmüller, Friederike
Medical Hypotheses , Volume 116 , 22 – 27
Women vs men & heart disease
Women are more likely to have coronary microvascular disease, which is damage to the small arteries of the heart. Men are more likely to have blocked coronary arteries, detected with an angiogram. Women may need an intravascular ultrasound in addition to an angiogram.
Coexisting conditions & mortality
Factors in people with heart failure significantly and independently associated with mortality included diabetes, chronic kidney disease, cerebrovascular disease, depression, cognitive impairment, and loss of function.
Murad K et al. Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: The Cardiovascular Health Study. JACC Heart Fail 2015 Jul; 3:542. (http://dx.doi.org/10.1016/j.jchf.2015.03.004)
http://www.jwatch.org/na38541/2015/08/05/coexisting-conditions-and-heart-failure-outcomes?query=etoc_jwhospmed
Blood sugar and heart disease
Blood sugar spikes after eating (postprandial) may predict cardivascular disease death. Lowering postprandial blood sugar may be essential in reversing heart disease deaths.
Sugar raises triglycerides & makes cholesterol more sticky & able to attach & block arteries
What may help lower blood sugar after eating & clear arteries:
avoiding sugar/high fructose corn syrup & carbohydrates without fiber
alpha lipoic acid & β-alanine which appears to reduce blood sugar & stops diabetes side effects like neuropathy
doctor prescribed metformin, which stops the progression of diabetes, reduces cancer 40%, & reduces mortality 15% (over someone with no diabetes) and supplementation with ubiquinal (a version of coQ10)/methycobalamin spray (a version of vitamin B12)/vitamin K2 which metformin lowers
Ginger before or in every meal
mulberry leaf extract before every meal
hibiscus tea before every meal
glucommanan fiber before meals
two tablespoons of vinegar (red wine best) before/during every meal, either in the ingredients (sweet & sour) or in balsamic dressings (with no sugar)
drinking a half glass of water before any other drink and before every meal
avoiding wheat which has a component that raises blood sugar as much as fructose
substituting sugar & especially fructose with stevia, monk fruit, and/or erythritol
walk or exercise right before or immediately after every meal or snack that raises blood sugar
Heart attacks and aspirin (75% reduction)
Taking half (40mg) of a baby aspirin before bedtime and half in the morning after waking up appears to reduce the chances of a second heart attack by 75% in one study with no significant increase in bleeding or ulcers. A daily aspirin also appears to lower recidivism of all gastrointestinal cancers by 50% and breast cancer as well.
Time-dependent effects of aspirin on blood pressure and morning platelet reactivity: a randomized cross-over trial.
Bonten TN et al.
Hypertension. 2015 Apr;65(4):743-50. doi: 10.1161/HYPERTENSIONAHA.114.04980. Epub 2015 Feb 17.
Are most heart attacks in the morning because of dehydration?
“When you drink water?
A lot of people say they don’t like drinking water before bed so they don’t have to get up at night to go to the bathroom.
I didn’t know, but it’s interesting…
I asked my cardiologist because people should pee so much at night. His answer was:
When a person is seated, the force of gravity retains the water at the bottom of his body.
This is why the legs tend to swell up.
When you go to bed, the lower part of your body is looking for a balance with your kidneys.
So the kidneys remove the water along with the waste, because that is the most propitious moment.
Water is essential to eliminate waste from its body.
I asked the cardiologist what the most favorable time to drink water.
He replied: water must be watered at the most precise moments so that its effectiveness within the body is maximum.
2 glasses of water shortly after the alarm clock activates the internal organs.
1 Glass of water 30 minutes before each meal improves digestion.
1 Glass of water before taking a bath (or two) decreases blood pressure.
1 Glass of water before bed, avoid a stroke or heart attack.
Drinking water before bed avoids having leg cramps during the night.
When there’s cramps, the muscles in the legs are looking for water and humidity.”
Aspirin for blood clots
Taking 100mg of aspirin once daily for two years appeared to reduce blood clots by 42% in one study. Taking aspirin twice daily may approach the effectiveness of warfarin or Clopidogrel (Plavix), and aspirin has anti-inflammatory/antipain & anticancer benefits as well. Aspirin is also especially effective against heart attacks when taken before bed & upon awakening.
The safest way that appears to prevent bleeding the most is a half a baby aspirin before bed and half a baby aspirin upon waking up.
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.012235
Circulation. 2014;130:1031-1033
Heart attacks
Injected glatiramer acetate given for a couple months after a heart attack reduced scarring to minimal & improved blood flow 30% in rats & mice.
theepochtimes.com/health/old-drug-could-be-new-healing-aid-for-heart-attack-victims-5718309?ea_src=ai_recommender&ea_med=desktop_health
Pycnogenol to prevent deep vein thromobosis
Taking pycnogenol appears to be more effective than than compression stockings for leg/ankle swelling & leg pain and far better tolerated both for long term DVT prevention & during long flights or car rides.
Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study.
Panminerva Med. 2011 Sep;53(3 Suppl 1):21-7.
Healthline: https://www.healthline.com/health/post-thrombotic-syndrome
CDC: https://www.cdc.gov/ncbddd/dvt/data.html
Mayo Clinic: https://www.mayoclinic.org/diseases-conditions/deep-vein-thrombosis/symptoms-causes/syc-20352557
https://www.webmd.com/dvt/news/20050812/pine-bark-extract-may-prevent-leg-clots#1
https://www.lifeextension.com/Magazine/2017/1/Natural-Prevention-Of-Deep-Vein-Thrombosis/Page-01
Warfarin (Coumadin)
Warfarin is used to prevent blood clots, but needs expensive weekly monitoring. Warfarin is an anticholinergic that may cause dementia symptoms & increases mortality (early death). It may cause greater internal bleeding in women than men.
https://www.uea.ac.uk/mac/comm/media/press/2011/June/Anticholinergics+study+drug+list
http://doublecheckmd.com/EffectsDetail.do?dname=clonidine&sid=11980&eid=5692
Aspirin vs warfarin
Warfarin was no better than aspirin in one study at preventing deaths in people with heart failure, and aspirin is far cheaper both in cost & because it doesn’t require expensive weekly monitoring. It also has a beneficial anti-inflammatory pain killing benefit warfarin doesn’t.
Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm
Shunichi Homma et al.
N Engl J Med 2012; 366:1859-1869May 17, 2012DOI: 10.1056/NEJMoa1202299
Clopidogrel (Plavix)
Clopidogrel has not been found significantly better than aspirin for preventing heart attacks or strokes, and can increase deaths from bleeding. Clopidogrel may increase heart attacks if blood pressure or LDL cholesterol is high. It appears to be especially deadly when given with aspirin.
Effects of Clopidogrel Added to Aspirin in Patients with Recent Lacunar Stroke
The SPS3 Investigators
N Engl J Med 2012; 367:817-825August 30, 2012DOI: 10.1056/NEJMoa1204133
http://www.healthline.com/health-news/plavix-5000-suing-drug-maker
Dabigatran (Pradaxa)
Dabigatran is prescribed to prevent clots & stroke from atrial fibrillation or recurrent clots after hip or knee replacement. Dabigatran increased gastrointestinal bleeding/upset & bleeding around the spine & brain. It is dangerous in people with mechanical prosthetic heart valves. It increases heart attacks & GERD. Dabigatran was reported by doctors to the FDA as having cause 2x as many adverse events & deaths as warfarin & more than any other drug in 2011. Dabigatran needs to be withdrawn slowly & with aspirin or another blood thinner to prevent rebound stroke.
Pradaxa Adverse Event Reports Indicate Numerous Bleeding-Related Deaths
https://www.drugs.com/pradaxa.html
Proton pump inhibitors (PPIs)
PPIs are used to treat GERD/acid reflux, lowering acid in the stomach. They may cause heart disease/heart attack deaths and increase pneumonia by 300%, deadly c-difficile infections (CDI), dementia, cancer and kidney failure. H2 blockers also lower acid and may have the same problems as PPIs. D-limonene from orange peels, DGL licorice, mastic gum, slippery elm, and/or marshmallow root may help without the possibly deadly side effects of the PPIs or H2 blockers.
Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population
Nigam H. Shah , Paea LePendu , Anna Bauer-Mehren, Yohannes T. Ghebremariam, Srinivasan V. Iyer, Jake Marcus, Kevin T. Nead, John P. Cooke, Nicholas J. Leeper
DOI: 10.1371/journal.pone.0124653
DPP-4 inhibitors for diabetes increase heart failure except sitagliptin, which was no better than placebo over three years at preventing heart failure.
DOI: 10.1056/NEJMoa1501352
What may help:
Vitamin D3
Taking 4000 IU of vitamin D3 with a meal or vegetable oil (fat soluble) may prevent & treat congestive heart failure, at least in part by reducing blood pressure & reducing the calcification of the arteries (& building bone).
Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial
Stefanie S Schleithoff, Armin Zittermann, Gero Tenderich, Heiner K Berthold, Peter Stehle, and Reiner Koerfer
Am J Clin Nutr April 2006 vol. 83 no. 4 754-759
Bone Mass, Vitamin D Deficiency, and Hyperparathyroidism in Congestive Heart Failure
Elizabeth Shane, MD, , Donna Mancini, MD, Keith Aaronson, MD, Shonni J. Silverberg, MD, Markus J. Seibel, MD, Vicki Addesso, Donald J. McMahon, MS
The American Journal of Medicine
Volume 103, Issue 3, September 1997, Pages 197â 207
Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
Armin Zittermann, PhD; Stefanie Schulze Schleithoff; Gero Tenderich, MD; Heiner K Berthold, MD, PhD; Reiner Körfer, MD; Peter Stehle, PhD
J Am Coll Cardiol. 2003;41(1):105-112. doi:10.1016/S0735-1097(02)02624-4
Vitamin D insufficiency in congestive heart failure: Why and what to do about it?
Armin Zittermann, Stefanie S. Schleithoff, Reiner Koerfer
Heart Failure Reviews
March 2006, Volume 11, Issue 1, pp 25-33
Association of Vitamin D Deficiency with Heart Failure and Sudden Cardiac Death in a Large Cross-Sectional Study of Patients Referred for Coronary Angiography
Stefan Pilz, Winfried März, Britta Wellnitz, Ursula Seelhorst, Astrid Fahrleitner-Pammer, Hans P. Dimai, Bernhard O. Boehm, and Harald Dobnig
The Journal of Clinical Endocrinology & Metabolism Volume 93, Issue 10
DOI: http://dx.doi.org/10.1210/jc.2008-0784
Ouabain (prescription drug) & strophanthus extract
Ouabain is a drug synthesized from the plant strophanthus that used to be prescribed to most people with heart problems. Ouabain fell out of favor to newer, more expensive drugs and is no longer prescribed but a liquid extract of strophanthus seeds is currently being used by more & more European (& German) cardiac clinics to treat heart problems.
One reason that Ouabain fell out of favor was because it was thought to have too much absorption variability when taken orally. The liquid strophanthus plant extract being used now is taken sublingually (under the toungue) and appears to have a much more reliable effect than was suggested when Ouabain was taken orally.
Ouabain use was also reduced by confusion about its relation to digitalis (both heart glycosides), a medicine limited because it inhibits (slows) the sodium pump. People assumed that Ouabain was the same, but both Ouabain & the current strophanthus extract has the opposite effect on the sodium pump as digitalis. Ouabain & strophanthus extract in low doses appears to stimulate the sodium pump, which may be why strophanthus is so effective against heart attack & angina.
Strophanthus stops angina & heart attacks
Strophanthus extract appears to be very effective in stopping both angina symptoms and the progression of & reducing the damage from myocardial infarction (heart attack). Strophanthus extract also appears to improve microcirculation of the blood as well as aspirin or Plavix without increasing bleeding and to stop heart muscle lactic acid buildup that leads to heart attacks, converting it to pyruvate.
When strophanthus extract is taken sublingually (under the toungue) it appears to reduce angina & heart attack symptoms & damage within minutes consistently. People taking it daily as a preventative and to treat congestive heart failure usually start by using a drop at a time under the tongue without swallowing for five minutes, increasing the number of drops per day throughout the day slowly until they find the dose that works best for them.
Because strophanthus extract appears to reduce angina, stop myocardial infarctions, thin the blood, and stop heart muscle lactic acid buildup all with low side effects when used sublingually, it may be essential to keep around for anyone with heart problems both for prevention & in case of a myocardial infarction.
Strophanthus & high blood pressure
Strophanthus appears to help reduce high blood pressure and lower the oxygen needs of the heart, improving respiration without the side effects of the beta blockers.
Strophanthus extract is produced in a compound pharmacy in Germany & one in South America. Here in the US it is available from a doctor:
Thomas S. Cowan, MD
661 Chenery Street
San Francisco, CA
94131
Fax : (415) 334-1014
Front Desk: (415) 334-1010
Dr. Cowan believes that most of the heart’s action is to diffuse the blood (it easily gets around even complete blockages), that blockages are the source of a small percentage of heart attacks, and that a decreased parasympathetic tone is the key..
He cites autopsy studies that find 82% of deadly heart attacks don’t occur at a blocked artery, and studies that find 66% of 50 yr old accident victims have at least one major coronary artery blocked by 90% or more with no reported symptoms.
Instead he suggests that a decreased parasympathetic tone caused by diabetes (along with decreased circulation, also with smoking), high blood pressure, long term stress and an immediate emotional, psychological, or physical stressor puts people in danger. The body shifts from burning fat to glycolytic fermentation of sugar, which creates lactic acid. That lactic acid causes pain & cramps labeled angina. Simple carbs may speed this process.
Unlike most muscles the heart cannot stop to get rid of the lactic acid, causing metabolic acidosis, calcium deficiency, & heart tissue damage & difficulty contracting. Clots are then a result of the pressure from the no longer moving blood in the arteries as it builds up.
Dr. Cowan believes that strophanthus is so effective by improving the action of the parasympathetic nervous system and by converting lactic acid to pyruvate, used for energy. It was the main treatment for angina & heart attack prevention for 20 years in Germany. It was so reliable a treatment that when people didn’t respond doctors knew that they did not have heart problems, called the strophanthus challenge test.
He also believes in Enhanced External Counterpulsation (EECP) instead of bypass (if no proximal left anterior descending (LAD) obstruction). One hours sessions of thigh & calve compression cuffs syncronized with EKG appears to create thousands of new capillaries, especially useful for heart failure and diastolic dysfunction. It lasts 5-8yrs, and may increase physical endurance & sexual function by 30%. EECP is covered by insurance for angina.
https://articles.mercola.com/sites/articles/archive/2016/12/18/heart-disease-treatment-options.aspx
Strophanthus hispidus attenuates the Ischemia-Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion
Rohit Gundamaraju et al.Pharmacogn Mag. 2014 Aug; 10(Suppl 3): S557–S562.
doi: 10.4103/0973-1296.139782
AGBAJE, E O; FAGEYINBO, M S. Evaluating Anti-Inflammatory activity of aqueous root extract of Strophanthus hispidus DC. (Apocynaceae). International Journal of Applied Research in Natural Products, [S.l.], v. 4, n. 4, p. 7-14, jan. 2012. ISSN 1940-6223. Available at: <http://www.ijarnp.org/index.php/ijarnp/article/view/87>. Date accessed: 16 jan. 2018.
Biol Pharm Bull. 2005 Dec;28(12):2319-22.
Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats.
Rao PR1, Kumar VK, Viswanath RK, Subbaraju GV.
Ouabain – the insulin of the heart
- Fürstenwerth
lnt J Clin Pract, November 2010, 64, 12, 1591-1594
doi: 10.1111/j.1742-1241.2010.02395.x
Effect of Strophanthus on Coronary Blood Flow and Cardiac Oxygen Consumption of Normal and Failing Human Hearts
- J. BING, F. M. MARAIST, J. F. DAMMANN, JR., A. DRAPER, JR., R. HEIMBECKER, R. DALEY, R. GERARD and P. CALAZEL
Circulation. 1950;2:513-516
doi: 10.1161/01.CIR.2.4.513
Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells
Paula F. Kinoshita, Lidia M. Yshii, Ana Maria M. Orellana, Amanda G. Paixão, Andrea R. Vasconcelos, Larissa de Sá Lima, Elisa M. Kawamoto & Cristoforo Scavone
Scientific Reports 7, Article number: 4894 (2017)
doi:10.1038/s41598-017-05075-9
Ouabain – the possible victory over the myocardial infarction” by Rolf-Jürgen Petry
https://www.humanheartcosmicheart.com/products/?hhch=7
https://bengreenfieldfitness.com/article/supplements-articles/what-is-strophanthus/
http://www.infarctcombat.org/heartnews-17.html
http://support.fourfoldhealing.com/article/78-medicine-strodival
http://ouabain.twoday.net/stories/886276/
https://www.humanheartcosmicheart.com/the-real-story-of-ouabain/
Olive oil
Olives or organic extra virgin olive oil appears to help reduce heart disease significantly, especially if used uncooked.
Organic extra virgin olive oil from one country (others are often faked or cut with less health oils) appears to help reverse heart disease more than just lowering total cholesterol or LDL cholesterol as well.
Here is the California Olive Oil Council certified oils:
https://www.cooc.com/seal-certified-oils/
https://www.popsugar.com/food/Real-Extra-Virgin-Olive-Oil-43133335
Cocoa & the heart
Organic cocoa has theobromine and has been found in multiple studies over the last 15 years to clean the arteries, reduce blood pressure, lower insuline resistance, reduce heart disease and lower mortality. The greatest flavenols are with organic cocoa, and dark chocolate from Endangered Species, Ghirardelli, and Lindt.
http://www.life-enhancement.com/magazine/article/2798-effect-of-treating-cocoa-with-alkali-the-dutching-process
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
Daniela Mastroiacovo et al.
The American Journal of Clinical Nutrition, Volume 101, Issue 3, 1 March 2015, Pages 538–548,https://doi.org/10.3945/ajcn.114.092189
Cocoa and the brain
Eating dark or sugar free chocolate appears to increase visual spatial memory & organization, working memory, scanning, tracking, abstract reasoning, & performance in the mini-mental state examination in one study over five years and nearly 1000 people independent of age, education, heart health, & diet. Eating chocolate appears to improve cognitive performance (even in Alzheimer’s & dementia), reduce mental fatigue, and improve mood.
Volume 100, 1 May 2016, Pages 126-132
Chocolate intake associated with better cognitive function: The Maine-Syracuse Longitudinal Study
Georgina E.Crichton, Merrill F.Elias, Ala’aAlkerwi
https://doi.org/10.1016/j.appet.2016.02.010
J Psychopharmacol. 2010 Oct;24(10):1505-14. doi: 10.1177/0269881109106923. Epub 2009 Nov 26.
Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort.
Scholey AB, French SJ, Morris PJ, Kennedy DO, Milne AL, Haskell CF.
Smith, H.J., Gaffan, E.A. & Rogers, P.J. Psychopharmacology (2004) 176: 412. https://doi.org/10.1007/s00213-004-1898-3
Methylxanthines are the psycho-pharmacologically active constituents of chocolate
Non Dutch/alkalyzed cocoa & chocolate only
Dutching/alkalyzing cocoa can reduce its health & heart improving phenol content by 92%. Organic, nonDutch/nonalkalyzed cocoa has the highest phenol content.
When mixing cocoa for a chocolate drink, avoid milk & sugar to get the greatest heart benefit. Stevia, monk fruit, & erythritol appear to be the safest noncaloric sweeteners.
Cocoa increases hdl, slowsLDL oxidation, cleans arteries, prevents cardiac deaths, stops aging skin, skin cancer & prevents sunburns, reverses chronic fatigue, & prevents diabetes & extends life. Two studies, one by Harvard med school dark chocolate improved blood flow & mental performance in elderly, another study helped people with mild cognitive impairment.
How often to eat?
For cognitive benefit, heart benefit, & to help stop type II diabetes, a measured amount of dark/sugarfree cocoa/chololate can be ingested every two to three hours. Doing this provides a cognitive boost throughout the day, helps clean out the heart, and and reduces often to zero the cravings for sweets, cakes, & cookies that worsen diabetes.
Sugar free chocolate/cocoa
Besides cocoa sweetened with your choice of stevia, erythritol, and/or monk fruit (all zero calories) alone or in combination, there are companies that make sugar free chocolate with erythritol. Most people find it doesn’t have the laxative or stomach cramping effect of sorbitol, mannitol, or xylitol. Best may be chocolate chips stored in the freezer- they last much longer in the mouth. Not only does cocoa & sugar free chocolate (as long as they are not Dutch or alkalyzed) apparently clear the arteries, they substitute successfully for cakes & cookies for most people.
Making your own sugar free chocolate bar
Organic cocoa powder (nondutch/nonalkalized is healthiest) can be mixed with water & sweetened with stevia, monk fruit and/or erythritol, a sugar alcohol that has no calories & may not cause the problems of xylitol, sorbitol, and mannitol. When using water use the exact amount in the recipe (look online)- too much or too little doesn’t taste good.
Sugar free chocolate bars can be made far cheaper by melting Baker’s brand baking chocolate (in the baking section) and adding the right amount of stevia, monk fruit, and/or erithritol.
Nitric oxide & nasal breathing
When we breathe through the nose we appear to make 25% more nitric oxide than when breathing through the mouth. This appears to help high blood pressure & congestive heart failure. Shallow nose breathing also appears to increase carbon dioxide levels & reduce anxiety & asthma. Exercising while consciously nose breathing appears to result in an increase in nose breath volume, making it easier to breathe exclusively though the nose during exercise over time.
Buteyko method
When we breathe small breaths in then out through the nose then hold our (empty) breath until we need to breath again & repeat that after 30 seconds of normal breathing again multiple times we increase our carbon dioxide levels & reduce some asthma medicine usage by 30- 50% (inhaled steroids) & some up to 90% (bronchodilators).
Beetroot juice
Beetroot juice has benefits both including & addition to nitrates that appear to significantly reduce both diastolic & systolic blood pressure, erectile dysfunction, raise HDL cholesterol & reduce LDL cholesterol, and improve exercise performance & endothelial function. For some people it works well enough to reduce their blood pressure medications & subsequent side effects.
Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure
A Double-Blind, Placebo-Controlled, Randomized TrialAndrew R. Coggan, Joshua L. Leibowitz, Catherine Anderson Spearie, Ana Kadkhodayan, Deepak P. Thomas, Sujata Ramamurthy, Kiran Mahmood, Soo Park, Suzanne Waller, Marsha Farmer, Linda R. Peterson
https://doi.org/10.1161/CIRCHEARTFAILURE.115.002141
Circulation: Heart Failure. 2015;8:914-920
FARMACIA, 2011, Vol. 59, 5 669 EFFECT OF BETA VULGARIS L. ON CHOLESTEROL RICH DIET-INDUCED HYPERCHOLESTEROLEMIA IN RATS MOHAMMED AL-DOSARI, SALEH ALQASOUMI , MAJID AHMAD , MOHAMMED AL-YAHYA , M. NAZAM ANSARI , SYED RAFATULLAH
Adv Nutr. 2017 Nov 15;8(6):830-838. doi: 10.3945/an.117.016717. Print 2017 Nov.
The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis.
Bahadoran Z1, Mirmiran P2, Kabir A3, Azizi F4, Ghasemi A5.
J Nutr. 2013 Jun;143(6):818-26. doi: 10.3945/jn.112.170233. Epub 2013 Apr 17.
Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis.
Siervo M1, Lara J, Ogbonmwan I, Mathers JC.
Eur J Nutr. 2016 Mar;55(2):451-459. doi: 10.1007/s00394-015-0872-7. Epub 2015 Mar 13.
Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis.
Lara J1, Ashor AW2,3, Oggioni C2, Ahluwalia A4, Mathers JC2, Siervo M2.
Int J Sport Nutr Exerc Metab. 2012 Feb;22(1):64-71.
Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists.
Cermak NM, Gibala MJ, van Loon LJ.
Probiotics
Probiotics including boulardii lower bad cholesterol & reduce heart disease and mortality.
Celery, cholesterol, blood pressure, gout, and inflammation/pain
Celery works as a beta blocker, an angiotensin-receptor blocker, and as a mild diuretic to lower blood pressure immediately, and it lowers LDL cholesterol and triglycerides and raises HDL cholesterol to clean the arteries & reduce blood pressure even greater in the long run. Celery may be the best single substance for lowering blood pressure. Celery seems to correct blood pressure, not just lower it. Unlike prescription blood pressure drugs that can lower the amount of blood that gets to the brain & cause dementia if blood pressure gets to low, celery appears to only lower blood pressure to normal- not lower blood pressure in people without high blood pressure.
Celery is also a COX-2 inhibitor & major anti-inflammatory/painkiller. Celery appears to prevent and treat gout as well as cherries do, in contrast to thiazide diuretics that can increase uric acid and cause gout.
Many people use a blender to liquify it, then add fruit & leafy greens and a little stevia to sweeten and a little veg oil to get the fat soluble nutrients benefits and for taste.
When taken in supplement form the best research is for ones that contain 85% 3nb.
Doctor Michael T. Murray has referenced many research studies on the effectiveness of celery.
http://doctormurray.com/celery-and-celery-seed-extract-are-powerful-proven-healers/
http://doctormurray.com/more-evidence-that-celery-seed-extract-lowers-high-blood-pressure/
Le QT and Elliott WJ: Hypotensive and hypocholesterolemic effects of celery oil may be due to BuPh. Clin Res 1991;39:173A.
Tsi D and Tan BKH: Cardiovascular pharmacology of 3-n-butylphthalide in spontaneously hypertensive rats. Phytotherapy Research 1997;11:576-82.
Le QT and Elliott WJ: Dose-response relationship of blood pressure and serum cholesterol to 3-n-butylphthalide, a component of celery oil. Clin Res 1991;39:750A.
Mimura Y, Kobayashi S, Naitoh T, Kimura I and Kimura M:The structure-activity relationship between synthetic butylidenephthalide derivatives regarding the competence and progression of inhibition in primary cultures proliferation of mouse aorta smooth muscle cells. Biol Pharm Bull 1995;18:1203-6.
Yu SR, Gao NN, Li LL,Wang ZY, Chen Y and Wang WN:The protective effect of 3-butyl phthalide on rat brain cells.Yao Hsueh Hsueh Pao 1988;23:656-61.
Chong ZZ and Feng YP: dl-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats. Chung Kuo Yao Li Hsueh Pao 1999;20:509- 12.
Chong ZZ and Feng YP: dl-3-n-butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats. Chung Kuo Yao Li Hsueh Pao 1999;20:696-700.
Yan CH, Feng YP and Zhang JT: Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats. Chung Kuo Yao Li Hsueh Pao 1998;19:117-20.
Lin JF and Feng YP: Effect of dl-3-n-butylphthalide on delayed neuronal damage after focal cerebral ischemia and intrasynaptosomes calcium in rats.Yao Hsueh Hsueh Pao 1996;31:166-70.
Liu XG and Feng YP: Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia.Yao Hsueh Hsueh Pao 1995;30:896-903.
Zhang LY and Feng YP: Effect of dl-3-n-butylphthalide (NBP) on life span and neurological deficit in SHRsp rats.Yao Hsueh Hsueh Pao 1996;31:18-23.
Zheng G, Kenney PM, Zhang J and Lam KT: Chemoprevention of benzopyrene-induced forestomach cancer in mice by natural phthalides from celery oil. Nutr Cancer 1993;19:77-86.
Soundararajan S and Daunter B: Ajvine: Pilot biomedical study for pain relief in rheumatic pain. School of Medicine,The University of Queensland, Brisbane, Queensland, Australia, 1991- 92.
Venkat S, Soundararajan S, Daunter B and Madhusudhan S. Use of Ayurvedic medicine in the treatment of rheumatic illness. Department of Orthopaedics, Kovai Medical Center and Hospitals, Coimbatore, India, 1995.
Hu D, Huang XX and Feng YP: Effect of dl-3-n-butylphthalide (NBP) on purine metabolites in striatum extracellular fluid in four-vessel occlusion rats.Yao Hsueh Hsueh Pao 1996;31:13-7
Chong ZZ and Feng YP: Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion. Chung Kuo Yao Li Hsueh Pao 1997;18:505-8.
Moghadam MH1, Imenshahidi M, Mohajeri SA. Antihypertensive effect of celery seed on rat blood pressure in chronic administration. J Med Food. 2013 Jun;16(6):558-63.
Magnesium
High blood pressure may often be caused by low magnesium levels. Tests often can’t give an accurate read on magnesium deficiency. One study found more than half of people admitted to the hospital were deficient in magnesium. The safer forms to take may be citrate, taurate, malate, glycinate, chloride, carbonate, threonate. Slow release may be most beneficial. Magnesium “oil” may also be applied topically, and people can soak in Epsom salt, which is magnesium sulphate.
www.naturalnews.com/046401_magnesium_dietary_supplements_nutrient_absorption.html#ixzz3THDO903K
People who may be especially vulnerable to a magnesium deficiency are people who drink a lot of alcohol, who have diabetes, who are on diuretics (often for blood pressure), who do excessive exercise (like marathons), and/or who have high stress or insomnia levels.
The RDA is 310-420mg daily, and many people take 500-1000mg. Topical magnesium can be very effective for pain & cramps, especially headaches & migraines. Topical DMSO is often used first to increase the speed of magnesium uptake. Magnesium appears to reduce insomnia, diabetes, migraines, muscle cramps, menstrual cramps, PMS symptoms, menopause symptoms, heart deaths, bone loss, anxiety, cognitive loss from Alzheimer’s. Many diseases are associated with low magnesium like mitral valve prolapse, high blood pressure, cardiac arrhythmias, migraines, ADHD, autism, anxiety, asthma, allergies, chronic pain, fibromyalgia, chronic fatigue, muscle spasms, insomnia, twitching & tremors, swelling/edema, weak pulse, brain fog/confusion, osteoporosis
www.naturalnews.com/046864_magnesium_mineral_deficiency_detox.html#ixzz3THFORnEE.
Magnesium is essential for using vitamins C & E, and along with zinc & vitamin K2 directs calcium away from the arteries & to the bones where its needed. Good magnesium levels are essential for cognitive function. Magnesium is very highly alkaline which helps to prevent & treat cancer taken both internally and used topically via magnesium chloride (magnesium oil).
What type of magnesium?
Magnesium citrate may help constipation.
Magnesium taurate may help blood pressure, cholesterol, and arrhythmias.
Magnesium malate & magnesium chloride may help fibromyalgia.
Magnesium glycinate may help anxiety, stress, and insomnia.
Magnesium carbonate may help heartburn, reflux, constipation, & dyspepsia.
Magnesium L-threonate may help memory & learning.
Magnesium sulfate may be very highly absorbed.
Magnesium oxide may be poorly absorbed.
Magnesium glutamate & aspartate may increase blood sugar & type II diabetes.
http://www.herbs-info.com/blog/the-best-and-worst-forms-of-magnesium-to-take-as-supplements/
Vitamin B9 (folate)
High homocysteine levels (perhaps above 8 µmol/L) appear to increase cardiovascular disease, congestive heart failure, and stroke. Many people (60% of the population, and 90% of people with depression) can’t use regular folate well which may contribute to high homocysteine levels. Taking methylfolate (methyl version of vitamin B9) may increase folate blood levels 700% higher than synthetic folate and may reduce homocysteine levels much lower. Lowering homocysteine may also reduce depression, dementia, bipolar disorder, anxiety, schizophrenia, migraines, age-related macular degeneration, and hearing loss.
What else lowers homocysteine-
vitamin B6, vitamin B12 (methylcobalamin may be best), betaine (TMG), vitamin B2, and magnesium
n-acetyl L-cysteine (NAC)
S-adenosylmethionine (SAMe)
taurine
green vegetables, especially dark green leafy vegetables
oranges
beans
exercise
What to avoid
the prescription drugs cholestyramine, colestipol, fenofibrate, levodopa, metformin, methotrexate, niacin, nitrous oxide, pemetrexed, phenytoin, sulfasalazine
red meat and dairy products
smoking
coffee
alcohol consumption
advancing age
obesity
Reduced B Vitamin Therapy in MTHFR C677T/A1298C Patients with Major Depressive Disorder – Clinical Response Correlates with Homocysteine Reduction: A Double-Blind, Placebo-Controlled Study
Arnie Mech and Andrew Farah
http://enlyterx.com/wp-content/uploads/2015/11/EnLyte-Clinical-Study-Reprint.pdf
https://globenewswire.com/news-release/2015/07/29/756168/10143796/en/Breakthrough-Depression-Study-Shows-42-Remission-Rate-With-EnLyte.html
http://www.drweil.com/health-wellness/body-mind-spirit/heart/elevated-homocysteine/
Infrared therapy to improve mood & concentration, and reduce anxiety
Near infrared therapy (NIR-A)
Near infrared therapy bulbs around 810-830nm wavelength (look for NIR-A label) appear to increase ATP energy production in tissue- reducing inflammation, speeding up healing times of injuries, wounds, & sore muscles by penetrating up to 9 inches (23cm). A 150W NIR-A infrared bulb can be bought for $10-$21 & used with a clampable lamp to target healing anywhere on the body 12 inches away for 15 minute applications every three hours. It should be pointed at bare skin as it doesn’t appear to work through clothing. Doing it more frequently or longer than 15 minutes at a time or closer than 12 inches from the lamp appears to negate the benefits. Near infrared therapy has been used by doctors and trainers for years to increase metabolism, energy, circulation, mood, concentration, endurance, strength, recovery, flexibility and reduce eye injuries & diseases, body fat, inflammation, joint & muscle pain, anxiety, depression, Alzheimer’s & Parkinson’s symptoms.
NIR-A and the heart
A 150 watt infrared bulb aimed at the heart might be effective for heart problems including congestive heart failure. The NIR-A may be most effective when used for 15 minutes every three hours pointing at bare skin 12 inches away. Doing it for longer or more frequently may reduce the benefit greatly.
Lasers Med Sci. 2016 Jul 1. [Epub ahead of print]
What is the best moment to apply phototherapy when associated to a strength training program? A randomized, double-blinded, placebo-controlled trial : Phototherapy in association to strength training.
Vanin AA et al.
Rojas JC, Gonzalez-Lima F. Low-level light therapy of the eye and brain. Eye and Brain. 2011;3:49–67.
J Clin Laser Med Surg. 2001 Dec;19(6):305-14.
Effect of NASA light-emitting diode irradiation on wound healing.
Whelan HT et al.
Ger Med Sci. 2006; 4: Doc05.
PMCID: PMC2703221
Influence of water-filtered infrared-A (wIRA) on reduction of local fat and body weight by physical exercise
Frank Möckel et al.
J Appl Physiol (1985). 2006 Jul;101(1):283-8. Epub 2006 Apr 20.
Effect of low-level laser (Ga-Al-As 655 nm) on skeletal muscle fatigue induced by electrical stimulation in rats.
Lopes-Martins RA, Marcos RL, Leonardo PS, Prianti AC Jr, Muscará MN, Aimbire F, Frigo L, Iversen VV, Bjordal JM.
ABOU-HALA, Andréia Zarzour et al. Effects of the infrared lamp illumination during the process of muscle fatigue in rats. Braz. arch. biol. technol. [online]. 2007, vol.50, n.3, pp.403-407. ISSN 1678-4324. http://dx.doi.org/10.1590/S1516-89132007000300006.
J Sports Med Phys Fitness. 2002 Dec;42(4):438-45.
Effect of linear polarized near-infrared light irradiation on flexibility of shoulder and ankle joints.
Demura S, Yamaji S, Ikemoto Y.
http://articles.mercola.com/sites/articles/archive/2017/02/26/photobiomodulation.aspx
http://drlwilson.com/articles/SAUNALITE%20NIR%20BENEFITS.htm
THE BENEFITS OF NEAR INFRARED ENERGY by Dr. Lawrence Wilson May 2010
http://drlwilson.com/articles/sauna_therapy.htm
Mulberry leaf extract
In one study mulberry leaf extract lowered fasting blood sugar by 27%, LDL by 30%, triglycerides by 16%, and raised HDL by 18%. Because blood sugar increase after eating predicts heart disease mortality, cutting blood sugar after eating is important for heart health.
http://www.lifeextension.com/Magazine/2016/10/Controlling-After-Meal-Blood-Sugar-Spikes/Page-01
Fiber
Fiber intake during meals lowers the risk of coronary heart disease. Organic freshly (or frozen) ground flaxseed may be best, followed by glucommanon capsules.
Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men.
Rimm EB et al.
JAMA. 1996 Feb 14;275(6):447-51.
Flaxseeds, heart disease & hypertension
Organic freshly ground flaxseeds appear to lower blood pressure in people with hypertension and to lower heart disease.
Rodriguez-Leyva D, Weighell W, Edel AL, Lavallee R, Dibrov E, Pinneker R, Maddaford TG, Ramjiawan B, Aliani M, Guzman R, Pierce GN. Potent antihypertensive action of dietary flaxseed in hypertensive patients. Hypertension. 2013;62(6):1081-9.
Antioxidant and Angiotensin Converting Enzyme-Inhibitory Properties of a Flaxseed Protein-Derived High Fischer Ratio Peptide Mixture
Chibuike C. Udenigwe and Rotimi E. Aluko
University of Manitoba, Winnipeg, MB R3T 2N2, Canada
- Agric. Food Chem., 2010, 58 (8), pp 4762–4768
DOI: 10.1021/jf100149w
DIETARY SUPPLEMENTATION OF FLAXSEED LOWERS CARDIOVASCULAR DISEASE RISK IN DIABETIC WISTER RATS.
International Journal of Academic Research . Mar2013, Vol. 5 Issue 2, p72-78. 7p.
Al-Bishri, Widad M.
Glucomannan lowers triglycerides, LDL cholesterol, and systolic blood pressure (and blood sugar, constipation, & weight)
Glucomannan is a fiber that comes from the root of a plant. It had no calories, and in numerous studies has been shown to help lower blood sugar, systolic blood pressure, LDL cholesterol, triglycerides (far more important to lower than cholesterol), constipation and weight. The capsule (tablets are unsafe) can be taken up to an hour before a meal or the powder can be used as a thickener (like corn starch). The strongest benefit appears to be taking 1g (two 500mg capsules) up to an hour before a meal. Glucomannan must be taken with a full glass of water (to avoid intestinal obstruction). It may cause an increase in gas (infrequently) the first couple of uses before the body gets used to it.
Shirataki noodles are made from glucomannan and have no calories. They are often rinsed to get rid of a fishy smell and mixed with tofu (tofu shirataki noodles) to better simulate noodles taste.
Arvill A, Bodin L. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Am J Clin Nutr. 1995;61:585-589.
Chua M, Baldwin TC, Hocking TJ, Chan K. “Traditional uses and potential health benefits of Amorphophallus konjac K. Koch ex N.E.Br.” J Ethnopharmacol. 2010 Mar 24;128(2):268-78.
Chen HL, Cheng HC, Wu WT, et al. Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial. J Am Coll Nutr. 2008;27:102-108
Chen HL, Sheu WH, Tai TS, et al. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects-a randomized double-blind trial. J Am Coll Nutr . 2003;22:36-42
Doi K. Effect of konjac fibre (glucomannan) on glucose and lipids. Eur J Clin Nutr. 1995;(suppl 3):190-197.
Gallaher, DD, et al. A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans. Journal of the American College of Nutrition Volume 21, Issue 5, 2002 DOI: 10.1080/07315724.2002.10719246
Gallaher, CM. et al. Cholesterol Reduction by Glucomannan and Chitosan Is Mediated by Changes in Cholesterol Absorption and Bile Acid and Fat Excretion in Rats. J. Nutr. November 1, 2000
vol. 130 no. 11 2753-2759
González Canga A, Fernández Martínez N, Sahagún AM, García Vieitez JJ, Díez Liébana MJ, Calle Pardo AP, Castro Robles LJ, Sierra Vega M. “Glucomannan: properties and therapeutic applications.” Nutr Hosp. 2004 Jan-Feb;19(1):45-50.
Keithley J, Swanson B. “Glucomannan and obesity: a critical review.” Altern Ther Health Med. 2005 Nov-Dec;11(6):30-4.
Loening-Baucke V, Miele E, Staiano A. “Fiber (glucomannan) is beneficial in the treatment of childhood constipation.” Pediatrics. 2004 Mar;113(3 Pt 1):e259-64.
McCarty MF. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy. Med Hypotheses. 2002 Jun;58(6):487-90.
Reffo GC. Glucomannan in hypertensive outpatients: pilot clinical trial. Curr Ther Res . 1988;44:22-27.
Reffo GC, Ghirardi PE, Forattani C. Double-blind evaluation of glucomannan versus placebo in postinfarcted patients after cardiac rehabilitation. Curr Ther Res. 1990;47:753-758.
Signorelli P, Croce P, Dede A. Clinical study on the use of a glucomannan and lactulose association in pregnancy constipation [in Italian; English abstract]. Minerva Ginecol. 1996;48:577-582.
Sood N, Baker WL, Coleman CI. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Am J Clin Nutr. 2008;88:1167-1175.
Staiano A, Simeone D, Del Giudice E, et al. Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children. J Pediatr . 2000;136:41-45.
Vita PM, Restelli A, Caspani P, Klinger R. Chronic use of glucomannan in the dietary treatment of severe obesity. Minerva Medica [1992, 83(3):135-139]
Vuksan, V et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care January 2000 vol. 23 no. 1 9-14 doi: 10.2337/diacare.23.1.9
Vuksan V, Jenkins DJ, Spadafora P, et al. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care . 1999;22:913-919.
Venter CS, Kruger HS, Vorster HH, et al. The effects of dietary fiber component konjac-glucomannan on serum cholesterol levels of hypercholesterolemic subjects. Hum Nutr Food Sci Nutr. 1987;41F:55-61
Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes . 1984;8:289-293
Yoshida, M et al. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes European Journal of Clinical Nutrition (2006) 60, 529–537. doi:10.1038/sj.ejcn.1602347; published online 4 January 2006
Coffee
Coffee appears to reduce deaths from heart disease, but only if filtered successfully. Coffee grounds have a chemical in them that increase heart disease. Percolated & expresso coffee is safe if run through a paper filter after brewing.
Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women’s Health Study
Lene Frost Andersen et al.
Am J Clin Nutr May 2006
vol. 83 no. 5 1039-1046
Coffee with coffee grounds in it, from the older percolators or newer expresso machines, causes heart disease & increases mortality.
The cholesterol-raising factor from coffee beans.
R Urgert and M B Katan
J R Soc Med. 1996 Nov; 89(11): 618–623.
PMCID: PMC1295997
Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial1,2,3
Marina J Grubben et al.
Am J Clin Nutr February 2000
vol. 71 no. 2 480-484
Coffee made with older percolators or new expresso machines can be run through a paper filter to strain out the coffee grounds.
Vitamin K2
Taking vitamin K2 also (like vitamin D3) appears to reduce calcification of the arteries & builds bone.
Mod Rheumatol. 2013 Sep;23(5):1001-7. doi: 10.1007/s10165-012-0789-4. Epub 2012 Nov 6.
Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis.
Ebina K1, Shi K, Hirao M, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H, Hashimoto J.
Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10. doi: 10.1016/j.numecd.2008.10.004. Epub 2009 Jan 28.
A high menaquinone intake reduces the incidence of coronary heart disease.
Gast GC1, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT.
Cordyceps mushroom
Treatment of arrhythmias with cordyceps has a an 82% success rate on average in one study, including a majority of people with superventricular arrhymia, ventricular arrhythmia or complete blockage of the right branch ECG recovery, tachyarrhythmia & brachyarrhythmia, including premature beats. Cordyceps may lower total cholesterol, triglycerides, & beta lipoprotein (low density cholesterol).
In people with heart failure, cordyceps may increase cardiac stroke volume and cardiac index, general physical & emotional well being and quality of life & reduces heart rate, shortness of breath, & fatigue.
Mushrooms appear to need to be cooked to get their benefits, even if they come in a capsule.
The Scientific Rediscovery of a Precious Ancient Chinese Herbal Regimen: Cordyceps sinensis Part II
Jia-Shi Zhu, Georges M. Halpern, Kenneth Jones
The Journal of Alternative and Complementary Medicine. Winter 1998, 4(4): 429-457.
doi:10.1089/acm.1998.4.429.
Hawthorn berry
900-1800 mg of hawthorn daily may prevent & treat arrhythmia, congestive heart failure CHF, angina, arteriosclerosis, myocarditis, diarrhea, insomnia, plaque, clots, and kidney problems. Hawthorn appears to increases exercise ability in people with CHF.
Efficacy of the Hawthorn (Crataegus) preparation LI 132 in 78 patients with chronic congestive heart failure defined as NYHA functional class II
- Schmidt*, U. Kuhn, M. Ploch, W.-D. HübnerPhytomedicine
Volume 1, Issue 1, June 1994, Pages 17â 24
A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan ®) in the treatment of patients with congestive heart failure NYHA II
F.H. Degenringa, A. Sutera, M. Webera, R. Sallerb
Phytomedicine
Volume 10, Issue 5, 2003, Pages 363â 369
Hawthorn: pharmacology and therapeutic uses
JM Rigelsky and BV Sweet
American Journal of Health-System Pharmacy March 1, 2002 vol. 59 no. 5 417-422
Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials
Max H Pittler, MD, Katja Schmidt, MS, Edzard Ernst, MD, PhD
The American Journal of Medicine
Volume 114, Issue 8, 1 June 2003, Pages 665â 674
Hawthorn
Dr. Qi Chang PhD, Dr. Zhong Zuo PhD, Dr. Francisco Harrison MD, Dr. Moses Sing Sum Chow PharmD
DOI: 10.1177/00970002042006003
The Journal of Clinical Pharmacology
Volume 42, Issue 6, pages 605â 612, June 2002
Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure
Michael Tauchert, Prof Dr med
American Heart Journal
Volume 143, Issue 5, May 2002, Pages 910â 915
Blood pressure monitoring
For people who had uncontrolled high blood pressure, home monitoring helped 79% quickly gain control and reduced the need for doctor visits.
American Heart Association. “Monitoring at home yields better blood pressure control.” ScienceDaily. ScienceDaily, 9 September 2018. <www.sciencedaily.com/releases/2018/09/180909103208.htm>.
Medicinal mushroom mix
Taking a mix of the medicinal organic mushrooms may lower bad cholesterol, reduce cancer, and reduce infections. Mushrooms appear to need to be cooked to get the benefit, even if they come in capsule form.
Coenzyme Q/CoQ10/ubiquinol
60-100mg of coenzyme Q10/CoQ10 helps people with congestive heart failure. Ubiquinol is the most effective form of CoQ10. It slows atherosclerosis, lowers inflammation, improves ischemia and reperfusion injury of coronary revascularisation, as well as exercise in people with CHF & hypertension. The drugs that may lower coQ10 and require cosupplementation are beta blockers & hydrochlorothiazide (blood pressure drugs), statins taken for cholesterol, and metformin for diabetes.
In one study of 17 patients given coQ10 supplementation-
Heart function improved by 20%, and the mean CHF score increased significantly.
Left ventricular ejection fraction (a measure of the heart’s capacity to pump efficiently) improved nearly 35%.
Cardiac output improved by 15.7%.
Stroke volume index improved nearly 19%.
Systolic blood pressure decreased by 4.4%.
End-diastolic volume area decreased by 8.4%.
Mean exercise duration improved by 25.4%.
Cardiac workload improved by 14.3%.
http://www.lifeextensionvitamins.com/conhearfail.html#sthash.8rZHmyjr.dpuf
Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis1,2,3
A Domnica Fotino, Angela M Thompson-Paul, and Lydia A Bazzano
doi: 10.3945/â ajcn.112.040741
Am J Clin Nutr February 2013
Coenzyme Q10 in cardiovascular disease with emphasis on heart failure and myocardial ischaemia
Peter H. Langsjoen, MD, FACC, Alena M. Langsjoen, MS
The Asia Pacific Heart Journal
Volume 7, Issue 3, December 1998, Pages 160â 168
Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome
Adarsh Kumar, Harharpreet Kaur, Pushpa Devi, Varun Mohan
Pharmacology & Therapeutics
Volume 124, Issue 3, December 2009, Pages 259â 268
Journal of the International Society of Sports Nutrition
March 2008, 5:8,
Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
Matthew Cooke, Mike Iosia, Thomas Buford, Brian Shelmadine, Geoffrey Hudson, Chad Kerksick, Christopher Rasmussen, Mike Greenwood, Brian Leutholtz, Darryn Willoughby, Richard Kreider
Coenzyme Q10 Supplementation and Heart Failure
Uma Singh , Sridevi Devaraj , Ishwarlal Jialal
Nutrition Reviews Volume 65, Issue 6 Pp. 286 – 293
DOI: http://dx.doi.org/10.1111/j.1753-4887.2007.tb00306.x 286-293
Molecular and Cellular Biochemistry
April 2003, Volume 246, Issue 1-2, pp 75-82
Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
Ram B. Singh, Narankar Singh Neki, Kumar Kartikey, Daniel Pella, Adarsh Kumar, Mohammad Arif Niaz, Amar Singh Thakur
Role of Coenzyme Q10 in Chronic Heart Failure, Angina, and Hypertension
Dr. Mongthuong T. Tran Pharm.D.1, Dr. Tina M. Mitchell Pharm.D.2, Dr. Daniel T. Kennedy Pharm.D.3,* andDr. Joel T. Giles Pharm.D.4
DOI: 10.1592/phco.21.9.797.34564
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume 21, Issue 7, pages 797â 806, July 2001
The clinical investigator
August 1993, Volume 71, Issue 8 Supplement, pp S134-S136
Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
Prof. C. Morisco, B. Trimarco, M. Condorelli
European Heart JournalVolume 27, Issue 22Pp. 2675 – 2681
Coenzyme Q10 and exercise training in chronic heart failure
Romualdo Belardinelli , Andi Muçaj , Francesca Lacalaprice , Maridia Solenghi , Giovanna Seddaiu , Federica Principi , Luca Tiano , Gian Paolo Littarru
DOI: http://dx.doi.org/10.1093/eurheartj/ehl158 2675-2681
Journal of Cardiovascular Nursing:
July 2002 – Volume 16 – Issue 4 – pp 9-20
Alternative Medicines for Cardiovascular Diseases
Coenzyme Q10 and Cardiovascular Disease: A Review
Sarter, Barbara PhD
L-carnitine
The amino acid L-carnitine ingestion (2g/day) appears to significantly improve symptoms in people with congestive heart failure, increasing exercise ability, and improving survival.
Beneficial effects of propionyl l-carnitine on sarcolemmal changes in congestive heart failure due to myocardial infarction
Rajat Sethi , Ken S. Dhalla , Pallab K. Ganguly , Roberto Ferrari , Naranjan S. Dhalla
Cardiovascular Research Volume 42, Issue 3 Pp. 607 – 615
DOI: http://dx.doi.org/10.1016/S0008-6363(99)00089-9 607-615
The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure
(PMID:1493661)
Pucciarelli G, Mastursi M, Latte S, Sacra C, Setaro A, Lizzadro A, Nolfe G
Servizio di Cardiologia, USL n. 42, Ospedale Elena D’Aosta, Napoli.
La Clinica Terapeutica [1992, 141(11):379-384]
Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration
Ioannis Rizos, MD
American Heart Journal
Volume 139, Issue 2, Supplement 2, February 2000, Pages s120â s123
Coronary Artery Disease:
February 2004 – Volume 15 – Issue 1 – pp 65-71
Improvement of cardiac function and β-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction
Sethi, Rajata; Wang, Xia; Ferrari, Robertob; Dhalla, Naranjan S.a
Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure.
Mancini M, Rengo F, Lingetti M, Sorrentino GP, Nolfe G
Università degli Studi di Napoli, II Facoltà di Medicina e Chirurgia, Italy.
Arzneimittel-Forschung [1992, 42(9):1101-1104]
Japanese Circulation Journal
Vol. 56 (1992-1993) No. 1 P 86-94
http://doi.org/10.1253/jcj.56.86
L-Carnitine Treatment for Congestive Heart Failure : Experimental and clinical study : CURRENT THERAPY OF INTRACTABLE HEART FAILURE
Akira Kobayashi, Yoshinori Masumura, Noboru Yamazaki
Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure.
Ghidini O, Azzurro M, Vita G, Sartori G
Reparto Medicina Interna, Ospedale Bussolengo, Verona, Italy.
International Journal of Clinical Pharmacology, Therapy, and Toxicology [1988, 26(4):217-220]
l-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure
Giorgio Vescovo, Barbara Ravara, Valerio Gobbo, Marco Sandri, Annalisa Angelini, Mila Della Barbera, Massimo Dona, Gianfranco Peluso, Menotti Calvani, Luigi Mosconi, Luciano Dalla Libera
American Journal of Physiology – Cell Physiology Published 1 September 2002 Vol. 283 no. 3, C802-C810 DOI: 10.1152/ajpcell.00046.2002
L-arginine
The amino acid L-arginine (nine grams per day) prolongs exercise duration and blood flow in people with congestive heart failure.
L-arginine supplementation prolongs exercise capacity in congestive heart failure.
(PMID:15226784)
Bednarz B, Jaxa-Chamiec T, Gebalska J, HerbaczyÅ ska-Cedro K, CeremuzyÅ ski L
Department of Cardiology, Postgranduate Medical School, Grochowski Hospital, Warsaw, Poland.
Kardiologia Polska [2004, 60(4):348-353]
Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure
Bella Koifman, MD; Yoram Wollman, PhD; Natalie Bogomolny, MD; Tamara Chernichowsky, MSc; Ariel Finkelstein, MD; Gary Peer, MD; Jack Scherez, BSc; Miriam Blum, MD; Shlomo Laniado, MD; Adrian Iaina, MD; Gad Keren, MD, FACC
J Am Coll Cardiol. 1995;26(5):1251-1256. doi:10.1016/0735-1097(95)00318-5
L-Arginine reduces heart rate and improves hemodynamics in severe congestive heart failure
Edimar Alcides Bocchi M.D.*, Alvaro Vilella De Moraes M.D., Antonio Esteves-Filho M.D., Fernando Bacal M.D., José Otavio Auler M.D., Maria José Carmona M.D., Giovanni Bellotti M.D. and Antonio Franchini Ramires M.D.
Clinical Cardiology
Volume 23, Issue 3, pages 205â 210, March 2000
DOI: 10.1002/clc.4960230314
Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral l-Arginine in Patients With Heart Failure
Thomas S. Rector, PhD; Alan J. Bank, MD; Kathleen A. Mullen, RN; Linda K. Tschumperlin, RN; Ronald Sih, MD; Kamalesh Pillai, MD; Spencer H. Kubo, MD
Circulation 1996; 93: 2135-2141
doi: 10.1161/01.CIR.93.12.2135
Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation
Rainer Hambrecht, MDa; Lutz Hilbrich, MDa; Sandra Erbs, BSca; Stephan Gielen, MDa; Eduard Fiehn, MDa; Nina Schoene, MDa; Gerhard Schuler, MDa
J Am Coll Cardiol. 2000;35(3):706-713. doi:10.1016/S0735-1097(99)00602-6
Citrulline
Our bodies make cirtrulline into arginine at higher levels than taking arginine directly & with less side effects (stomach upset). It helps open arteries & improve exercise.
Taurine
The amino acid taurine (2g 2x/day) helps slow the progression of congestive heart failure and improve survival.
Therapy of congestive heart failure with orally administered taurine.
Azuma J, Hasegawa H, Sawamura A, Awata N, Ogura K, Harada H, Yamamura Y, Kishimoto S
Clinical Therapeutics [1983, 5(4):398-408] (PMID:6871923)
The potential health benefits of taurine in cardiovascular disease
Yan-Jun Xu, MD PhD, Amarjit S Arneja, MD, Paramjit S Tappia, PhD, and Naranjan S Dhalla, PhD MD (Hon) DSc (Hon)
Exp Clin Cardiol. 2008 Summer; 13(2): 57â 65.
PMCID: PMC2586397
Therapeutic effect of taurine in congestive heart failure: A double-blind crossover trialâ
- Azuma M.D.*, A. Sawamura M.D., N. Awata M.D., H. Ohta M.D., T. Hamaouchi M.D., H. Harada M.D., K. Takihara M.D., H. Hasegawa M.D., T. Yamagami M.D., T. Ishiyama M.D., H. Iwata M.D. andS. Kishimoto M.D.
Clinical Cardiology
Volume 8, Issue 5, pages 276â 282, May 1985
DOI: 10.1002/clc.4960080507
Taurine: An overview of its role in preventive medicine
Barry S. Kendler, Ph.D.
Preventive Medicine
Volume 18, Issue 1, January 1989, Pages 79â 100
doi:10.1016/0091-7435(89)90056-X
American Heart Journal
Volume 112, Issue 6, December 1986, Pages 1278â 1284
Beneficial effect of taurine in rabbits with chronic congestive heart failure â
Keiko Takihara, M.D., Junichi Azuma, M.D., Nobuhisa Awata, M.D., Hideyuki Ohta, M.D., Tomoyuki Hamaguchi, M.D., Akihiko Sawamura, M.D., Yuya Tanaka, M.D., Susumu Kishimoto, M.D., Nick Sperelakis, Ph.D.
European Journal of Pharmacology
Volume 180, Issue 1, 3 May 1990, Pages 119â 127
The effects of taurine on atherosclerosis development in cholesterol-fed rabbits
Margaret A. Petty, Jacqueline Kintz, Giuseppe F. DiFrancesco
Journal of Cardiology
Volume 57, Issue 3, May 2011, Pages 333â 337
Effect of taurine supplementation on exercise capacity of patients with heart failure
Mohamad Reza Beyranvand, MD, Mahshid Kadkhodai Khalafi, MS, Valiollah Dabidi Roshan, PhD, Sirrus Choobineh, PhD, Saeid Alipour Parsa, MD, Mohammad Asadpour Piranfar, MD, PhD
D-ribose
D-ribose supplementation (5g/day) improves the quality of life, exercise and diastolic function in people with congestive heart failure.
D-ribose aids congestive heart failure patients
Heyder Omran, MD, Dean McCarter, PhD, John St Cyr, MD PhD, and Berndt Lüderitz, MD FESC FACC FAHA
Exp Clin Cardiol. 2004 Summer; 9(2): 117â 118.
PMCID: PMC2716264
D-Ribose Benefits Heart Failure Patients
Nampalli Vijay, Dean MacCarter, Linda M. Shecterle, and J.A. St. Cyr.
Journal of Medicinal Food
March 2008, 11(1): 199-200. doi:10.1089/jmf.2007.503.
The Patented Uses of D-Ribose in Cardiovascular Diseases
- Shecterle, Linda; R. Terry, Kathleen; A. St. Cyr, John
Recent Patents on Cardiovascular Drug Discovery, Volume 5, Number 2, June 2010, pp. 138-142(5)
D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study
Omran Heyder1,*, Illien Stefan1, MacCarter Dean2, St. Cyr John2 andLüderitz Berndt1
European Journal of Heart Failure
Volume 5, Issue 5, pages 615â 619, October 2003
DOI: 10.1016/S1388-9842(03)00060-6
d-Ribose, A Metabolic Substrate for Congestive Heart Failure
Susan Wagner RN1, James Herrick MSc, FASHP2, Linda M. Shecterle PhD3 andJohn A. St. Cyr MD, PhD2
Progress in Cardiovascular Nursing
Volume 24, Issue 2, pages 59â 60, June 2009
DOI: 10.1111/j.1751-7117.2009.00033.x
D-ribose aids advanced ischemic heart failure patients
Dean MacCarter, Nampalli Vijay, Melinda Washam, Linda Shecterle, , Helen Sierminski, J.A. St. Cyr
International Journal of Cardiology
Volume 137, Issue 1, September 2009, Pages 79â 80
D-Ribose Benefits Heart Failure Patients
Nampalli Vijay, Dean MacCarter, Linda M. Shecterle, and J.A. St. Cyr.
Journal of Medicinal Food March 2008, 11(1): 199-200. doi:10.1089/jmf.2007.503.
Alpha lipoic acid
Alpha lipoic acid (1g/day) appears to prevent heart damage, clean out the arteries by lowering triglycerides & vLDL, lower blood pressure, cause weight loss, reduce cancer, & stop pain/inflammation at even low doses against migraines, sciatica, nerve pain, & neuropathy, maintain cardiac function, improve endothelial function and reduce inflammation. It also appears to be the most effective substance against diabetes and it’s side effects.
Protective effect of dl-α-lipoic acid on cyclophosphamide induced oxidative cardiac injury
- Mythili, P.T. Sudharsan, E. Selvakumar, P. Varalakshmi,
Chemico-Biological Interactions
Volume 151, Issue 1, 30 December 2004, Pages 13â 19
Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation
A V Balachandar, K P Malarkodi, P Varalakshmi
Impact Factor:1.407 | Ranking:Toxicology 66 out of 87
Source:2013 Journal Citation Reports ® (Thomson Reuters, 2014)
Strategies to reduce oxidative stress in cardiovascular disease
Carlene A. HAMILTON, William H. MILLER, Sammy AL-BENNA, M. Julia BROSNAN, Russell D. DRUMMOND, Martin W. MCBRIDE and Anna F. DOMINICZAK
Clinical Science (2004) 106, (219â 234)
Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging
- Savitha, , K. Sivarajan, D. Haripriya, V. Kokilavani, C. Panneerselvam
Clinical Nutrition
Volume 24, Issue 5, October 2005, Pages 794â 800
Effect of POLY-MVA, a palladium α-lipoic acid complex formulation against declined mitochondrial antioxidant status in the myocardium of aged rats
N.P. Sudheesh, T.A. Ajith, K.K. Janardhanan, C.V. Krishnan
Food and Chemical Toxicology
Volume 48, Issue 7, July 2010, Pages 1858â 1862
Induction of endogenous antioxidants and phase 2 enzymes by α-lipoic acid in rat cardiac H9C2 cells: protection against oxidative injury â
Zhuoxiao Caoa, Maggie Tsanga, Hai Zhaob, Yunbo Lia
Biochemical and Biophysical Research Communications
Volume 310, Issue 3, 24 October 2003, Pages 979â 985
Mitochondrial Decay in the Aging Rat Heart
Evidence for Improvement by Dietary Supplementation with Acetyl-l-Carnitine and/or Lipoic Acid
TORY M. HAGEN, RÃ GIS MOREAU, JUNG H. SUH andFRANCESCO VISIOLI
Annals of the New York Academy of Sciences
Volume 959, Increasing Healthy Life Span: Conventional Measures and Slowing the Innate Aging Process pages 491â 507, April 2002
DOI: 10.1111/j.1749-6632.2002.tb02119.x
Irbesartan and Lipoic Acid Improve Endothelial Function and Reduce Markers of Inflammation in the Metabolic Syndrome
Results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) Study
Srikanth Sola, MD; Muhammad Q.S. Mir, MD; Faiz A. Cheema, MD; Nadya Khan-Merchant, PhD; Rekha G. Menon, MD; Sampath Parthasarathy, PhD; Bobby V. Khan, MD, PhD
Circulation 2005; 111: 343-348 doi: 10.1161/01.CIR.0000153272.48711.B9
Betaine
Betaine may help heart disease & congestive heart failure through lowering high homocycteine levels.
Betaine in human nutrition
Stuart AS Craig
Am J Clin Nutr September 2004 vol. 80 no. 3 539-549
Homocysteine: Role and implications in atherosclerosis
Sasidhar Guthikonda MD, MPH, William G. Haynes MD
Current Atherosclerosis Reports
2006, Volume 8, Issue 2, pp 100-106
Combinations
The nutrients l-citrulline, l-carnitine, coenzyme Q10, taurine, alpha-lipoic acid, betaine, glutamine, and d-ribose help chronic heart failure, myocardial infarction, angina pectoris, hypertension, hyperlipidemia, and lipoprotein.
Supplemental Conditionally Essential Nutrients in Cardiovascular Disease Therapy
Kendler, Barry S. PhD, FACN
Journal of Cardiovascular Nursing:
January/February 2006 – Volume 21 – Issue 1 – pp 9-16
Hawthorn, coenzyme Q (ubiquinol), carnitine, and arginine appear in multiple studies to help congestive heart failure.
Herbs and Dietary Supplements in the Prevention and Treatment of Cardiovascular Disease
Adriane Fugh-Berman MD
DOI: 10.1111/j.1520-037X.2000.80355.x
Issue Preventive Cardiology
Preventive Cardiology
Volume 3, Issue 1, pages 24â 32, Winter 2000
Ascorbic Acid (vitamin C)
Ascorbic acid (vitamin C) significantly helps endothelial recovery of in people with heart failure, diabetes, and atherosclerosis. Healthy endothelial function is essential to the funcioning of the heart & vascular system. High levels of vitamin C in the blood are associated with lower mortality & heart disease.
Vitamin C appears to help prevent atrial fibrillation after heart surgery.
Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis
Harri HemiläEmail author and Timo Suonsyrjä
BMC Cardiovascular DisordersBMC series – open, inclusive and trusted201717:49
DOI: 10.1186/s12872-017-0478-5
Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomized controlled trials.
Ashor AW, Lara J, Mathers JC, Siervo M.
Atherosclerosis. 2014;235;1:(9-20).
Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality: a Mendelian randomization study
Camilla J Kobylecki, Shoaib Afzal, George Davey Smith, and Børge G Nordestgaard
Am J Clin Nutr ajcn104497
doi: 10.3945/ajcn.114.104497
Plasma vitamin C predicts incident heart failure in men and women in European Prospective Investigation into Cancer and Nutrition-Norfolk prospective study.
Pfister R1, Sharp SJ, Luben R, Wareham NJ, Khaw KT.
Am Heart J. 2011 Aug;162(2):246-53. doi: 10.1016/j.ahj.2011.05.007. Epub 2011 Jul 7.
http://articles.mercola.com/sites/articles/archive/2015/08/03/vitamin-c-heart-disease.aspx?e_cid=20150803Z1_DNL_art_2&utm_source=dnl&utm_medium=email&utm_content=art2&utm_campaign=20150803Z1&et_cid=DM81280&et_rid=1061648443#_edn4
Atrial fibrillation (AF)
Digoxin for AF dangerous?
Patients given digoxin for AF may have a 56-71% higher risk of death and 63% higher risk of being hospitalized compared with patients not given digoxin for atrial fibrillation.
Alpha lipoic acid for AF
600mg of alpha lipoic acid at wakeup & with every meal may lower or eliminate atrial fibrillation within four months (if 200lbs or less).
Turkish Journal of Medical Sciences: Vol. 52: No. 4, Article 60. https://doi.org/10.55730/
1300-0144.5445 journals.tubitak.gov.tr/medical/vol52/iss4/60
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts
et al.
Pharmacol. Rep. (2014)
Alpha lipoic acid (ALA) & heart damage
ALA appears to stop heart damage & help the heart heal.
α-Lipoic acid alleviates myocardial injury and induces M2b macrophage polarization after myocardial infarction via HMGB1/NF-kB signaling pathway
et al. Alpha-lipoic acid impedes myocardial ischemia-reperfusion injury, myocardial apoptosis, and oxidative stress by regulating HMGB1 expression Eur. J. Pharmacol. (2022)
Saunas
Sauna usage appears to improve ventricular arrhythmias in people with chronic heart failure.
Effects of Repeated Sauna Treatment on Ventricular
Arrhythmias in Patients With Chronic Heart Failure
Takashi Kihara, MD; Sadatoshi Biro, MD; Yoshiyuki Ikeda, MD; Tsuyoshi Fukudome, MD;
Takuro Shinsato, MD; Akinori Masuda, MD; Masaaki Miyata, MD; Shuichi Hamasaki, MD;
Yutaka Otsuji, MD; Shinichi Minagoe, MD; Suminori Akiba, MD*; Chuwa Tei, MD
Circ J 2004; 68: 1146 â 1151
Endothilial cell function is essential to the health of the arteries & heart, especially in people with heart disease. Sauna usage improves endothilial, heart, & exercise functioning.
Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure.
Kihara T1, Biro S, Imamura M, Yoshifuku S, Takasaki K, Ikeda Y, Otuji Y, Minagoe S, Toyama Y, Tei C.
J Am Coll Cardiol. 2002 Mar 6;39(5):754-9.
Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters.
Ikeda Y1, Biro S, Kamogawa Y, Yoshifuku S, Eto H, Orihara K, Yu B, Kihara T, Miyata M, Hamasaki S, Otsuji Y, Minagoe S, Tei C.
Circ J. 2005 Jun;69(6):722-9.
Am J Cardiol. 2012 Jan 1;109(1):100-4. doi: 10.1016/j.amjcard.2011.08.014. Epub 2011 Sep 23.
Effect of repeated sauna treatment on exercise tolerance and endothelial function in patients with chronic heart failure.
Ohori T1, Nozawa T, Ihori H, Shida T, Sobajima M, Matsuki A, Yasumura S, Inoue H.
Sauna usage helps the functioning of people with heart failure
Exp Clin Cardiol. 2007 Spring; 12(1): 29â 32.
PMCID: PMC2359619
Clinical Cardiology: Review
Beneficial effects of sauna bathing for heart failure patients
Nava Blum, PhD1 and Arnon Blum, MD2
Using a sauna just twice weekly can increases endurance by 30%.
J Sci Med Sport. 2007 Aug;10(4):259-62. Epub 2006 Jul 31.
Effect of post-exercise sauna bathing on the endurance performance of competitive male runners.
Scoon GS1, Hopkins WG, Mayhew S, Cotter JD.
Using a sauna increases muscle growth & stops soreness.
Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading.
Selsby JT1, Rother S, Tsuda S, Pracash O, Quindry J, Dodd SL.
J Appl Physiol (1985). 2007 Apr;102(4):1702-7. Epub 2006 Nov 16.
Using a sauna can significantly increase insulin sensitivity & lower blood sugar levels.
Int J Hyperthermia. 2007 May;23(3):259-65.
Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice.
Kokura S1, Adachi S, Manabe E, Mizushima K, Hattori T, Okuda T, Nakabe N, Handa O, Takagi T, Naito Y, Yoshida N, Yoshikawa T.
Human growth hormone HGH prevents muscle loss & atrophy, as does testosterone. Levels of HGH drop off dramatically after the age of thirty, and testosterone drops significantly as well. Supplementing them artificially can increase cancer & have other serious physical & behavioral side effects. Sauna usage naturally raises HGH & testosterone levels.
Eur J Appl Physiol Occup Physiol. 1989;58(5):543-50.
Haemodynamic and hormonal responses to heat exposure in a Finnish sauna bath.
Kukkonen-Harjula K1, Oja P, Laustiola K, Vuori I, Jolkkonen J, Siitonen S, Vapaatalo H.
Using a sauna appears to prevent high blood pressure development (2-3X/wk 23% lower risk, 4-7X 46%)
Francesco Zaccardi, Tanjaniina Laukkanen, Peter Willeit, Setor K. Kunutsor, Jussi Kauhanen, Jari A. Laukkanen. Sauna Bathing and Incident Hypertension: A Prospective Cohort Study. American Journal of Hypertension, 2017; DOI: 10.1093/ajh/hpx102
Grounding
Grounding is simply walking barefoot on earth. Skin to earth contract transfers negative electrons which significantly reduce inflammation, stress and relieves pain. Grounding may help lower cardiovascular disease and death. Grounding appears to relieve muscle soreness and improve mood and sleep and reduce electric field sensitivity.
http://articles.mercola.com/sites/articles/archive/2017/02/25/grounding-recharge-immune-system-slow-aging.aspx?utm_source=dnl&utm_medium=email&utm_content=ms1&utm_campaign=20170305Z1_UCM&et_cid=DM135758&et_rid=1912368176
J Environ Public Health. 2012; 2012: 291541.
Published online 2012 Jan 12. doi: 10.1155/2012/291541
Earthing: Health Implications of Reconnecting the Human Body to the Earth’s Surface Electrons
Gaétan Chevalier et al.
J Inflamm Res. 2015 Mar 24;8:83-96. doi: 10.2147/JIR.S69656. eCollection 2015.
The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases.
Oschman JL et al.
J Altern Complement Med. 2013 Feb;19(2):102-10. doi: 10.1089/acm.2011.0820. Epub 2012 Jul 3.
Earthing (grounding) the human body reduces blood viscosity-a major factor in cardiovascular disease.
Chevalier G, Sinatra ST, Oschman JL, Delany RM.
J Altern Complement Med. 2010 Mar; 16(3): 265–273.
doi: 10.1089/acm.2009.0399
Pilot Study on the Effect of Grounding on Delayed-Onset Muscle Soreness
Dick Brown, Gaétan Chevalier, and Michael Hill
Psychol Rep. 2015 Apr;116(2):534-42. doi: 10.2466/06.PR0.116k21w5. Epub 2015 Mar 6.
The effect of grounding the human body on mood.
Chevalier G.
J Altern Complement Med. 2007 Nov;13(9):955-67.
Can electrons act as antioxidants? A review and commentary.
Oschman JL
Applewhite R. “The effectiveness of a conductive patch and a conductive bed pad in reducing induced human body voltage via the application of earth ground.” European Biology and Bioelectromagnetics 2005; 1: 23–40
http://www.earthingoz.com.au/pdf/Applewhite_earthing_body_voltage_2005.pdf
FDA determines NSAIDS cause heart attacks, strokes, atrial fillibration, and heart failure
Aspirin was made with salicylic acid, an extract from the bark of the willow tree and spiraea plant. Aspirin is a cyclooxygenase-2 (COX-2) inhibitor which is why it helps to lower pain & inflammation. All NSAIDs (like ibuprofen & naproxen) are aspirin derivatives (as well as the the non-NSAID acetominophen) & they are COX-2 inhibitors and also have aspirin’s problem of thinning the blood & causing ulcers and/or stomach pain, & unlike aspirin they increase atrial fibrilation/irregular heartbeat, heart attacks, heart failure & strokes (naproxen lowers heart attacks but mildly increases strokes). them causes bleeding, ulcers, heart attacks, & strokes, as well as atrial fibrilation/irregular heartbeat. Aspirin increases the risk of hemmhoragic strokes. The FDA is recommending limited or no use of NSAIDs. Aspirin & the NSAIDS also slow wound healing by reducing new blood vessels to the injury site (angiogenesis).
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing
Michael K. Jones et al.
Nature Medicine 5, 1418 – 1423 (1999)
doi:10.1038/70995
Studies on the mechanism of action of salicylate II. Retardation of wound healing by aspirin
- H. Lee
DOI: 10.1002/jps.2600570633
Journal of Pharmaceutical Sciences
Volume 57, Issue 6, pages 1042–1043, June 1968
Morten Schmidt, Morten Lamberts, Anne-Marie Schjerning Olsen, Emil Fosbøll, Alexander Niessner, Juan Tamargo, Giuseppe Rosano, Stefan Agewall, Juan Carlos Kaski, Keld Kjeldsen, Basil S. Lewis, Christian Torp-Pedersen. Cardiovascular safety of non-aspirin non-steroidal anti-inflammatory drugs: review and position paper by the working group for Cardiovascular Pharmacotherapy of the European Society of Cardiology. European Heart Journal, 2016; ehv505 DOI: 10.1093/eurheartj/ehv505
NSAIDs & congestive heart failure
NSAIDs usage may lead to congestive heart failure at greater rates than even gastrointestinal issues.
Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly PatientsAn Underrecognized Public Health Problem FREE
John Page, MBBS(Hons); David Henry, MBChB
Arch Intern Med. 2000;160(6):777-784. doi:10.1001/archinte.160.6.777
NSAIDs & heart attacks
NSAIDs appear to increase heart attacks, even after one usage for the next 30 days, some up to 50%.
NSAIDs and cardiac arrest: Non-steroidal anti-inflammatory drug use is associated with increased risk of Out-of-hospital Cardiac Arrest: A nationwide Case-Time-Control study
Kathrine Bach Sondergaard Gunnar Gislason
European Heart Journal, Volume 38, Issue 23, 14 June 2017, Pages 1788–1789, https://doi.org/10.1093/eurheartj/ehx267
https://www.fda.gov/Drugs/DrugSafety/ucm451800.htm
Peritoneal dialysis vs hemodialysis in kidney disease in congestive heart failure
Seven nights a week peritoneal dialysis is far better than three days a week hemodialysis for multiple outcome measures, including the prevention of congestive heart failure. Nightly (7) peritoneal dialysis even treats congestive heart failure that progressed under three days a week hemodialysis.
http://www.nature.com/ki/journal/v70/n103s/full/5001918a.html
http://europepmc.org/abstract/MED/17886609
http://jama.jamanetwork.com/article.aspx?articleid=663741
Cholesterol
HDL cholesterol, especially HDL2, cleans arteries and appears to prevent heart disease. Small particle LDL can cause artery blockage and damage, perhaps especially Lp(a) and remnant lipoprotein (RLP). High triglycerides are associated with heart disease. Large particle LDL is not strongly associated with heart disease, When bad small particle LDL levels (vLDL) are high (80% is triglycerides), bad triglyceride levels are often high and good HDL levels are often low.
HDL vs triglycerides far more important
So total cholesterol and total LDL levels may have little meaning. If small particle vLDL is mostly triglycerides, then what appears to be most important is that triglycerides are no more than `1.5 x HDL. If HDL is exactly 30, than a safer triglyceride level would be under 45. Over 45 then would indicate elevated heart attack risk.
Sugar-especially high fructose corn syrup- & white flour intake appears to be associated with increased triglycerides and increased small particle LDL cholesterol, both of which are associated with an increase in heart disease. Weight loss and exercise have been associated with a decrease in small particle LDL cholesterol and a decrease in triglycerides and an increase in HDL cholesterol-all changes associated with a lowering of heart disease.
Testing
The more discerning newer test may be the Lipoprotein Particle Profile (LPP) test, which can test for the different types of LDL & HDL, or the Vertical Auto Profile (VAP) test which can test for most of them.
HDL2 should perhaps be greater than 25 mg/dL.
HDL3 should perhaps be greater than 15 mg/dL.
Lp(a) should perhaps be lower than 30 mg/dL in the standard test, lower than 10mg/dL in a VAP test.
VLDL3 triglycerides should perhaps be less than 10 mg/dL.
Animal saturated fat
Animal saturated fat intake appears to be associated with increased large particle LDL levels, which does not appear to be associated with increased heart disease like small, dense particle vLDL. Animal (but not plant) saturated fat when fed corn & soy is also associated with increased cancer, with processed meat (bologna, hot dogs, sausage, bacon, canned meats, salami) having the highest association with cancer. Animal saturated fat fed this is also associated with a temporary decrease in cognitive function in the hours after ingestion.
Small LDL and Its Clinical Importance as a New CAD Risk Factor: A Female Case Study
- Robert Superko MD1, Mary Nejedly MS, ANP2 andBrenda Garrett RN1
DOI: 10.1111/j.0889-7204.2002.01453.x
Progress in Cardiovascular Nursing Volume 17, Issue 4, pages 167–173, Fall 2002
Comparison of High-Density and Low-Density Lipoprotein Cholesterol
Subclasses and Sizes in Asian Indian Women with Caucasian Women
from the Framingham Offspring Study
NARENDRA C. BHALODKAR et al.
Clin. Cardiol. 28, 247–251 (2005)
CLIN. CHEM. 36/1, 15-19 (1990) CLINICAL CHEMISTRY, Vol.36, No. 1, 1990 15
Estimating Low-Density Lipoprotein Cholesterol by the Friedewald Equation Is Adequate for Classifying Patients on the Basis of Nationally Recommended Cutpoints
- Russell Warnick, Robert H. Knopp, Virginia Fitzpatrick, and Lance Branson
600,000 patients
Chowdhury, R et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med 2014;160:398-406.
http://www.nbcnews.com/id/35058896/ns/health-heart_health/t/bad-cholesterol-its-not-what-you-think/#.V6jfZDWfJAE
https://en.wikipedia.org/wiki/Low-density_lipoprotein
http://www.drsinatra.com/defining-the-different-types-of-cholesterol/
http://www.drsinatra.com/why-your-cholesterol-test-can-lie/
http://www.drsinatra.com/healthy-cholesterol-levels-defined/
What may increase heart attacks?
An agonizing sports loss
Air pollution
Marijuana-5x risk in hour after smoking, 4x overall risk if smoke weekly
Erectile dysfunction (likely an indication of heart disease)
Bátkai, S., Pacher, P., Osei-Hyiaman, D., Radaeva, S., Liu, J., Harvey-White, J., Offertaler, L., Mackie, K., Rudd, M.A., Bukoski, R.D., and Kunos, G. (2004). Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension. Circulation, 110(14), 1996–2002. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756479/.
Mittleman, M.A., Lewis, R.A., Maclure, M., Sherwood, J.B., Muller, J.E. (2001). Triggering myocardial infarction by marijuana. Circulation, 103(23), 2805-9. Retrieved from http://circ.ahajournals.org/content/103/23/2805.
Bottom Line Personal, Vol 39, #1, 1/1/18 Being a Sports Fan Can Kill You Gregory S. Thomas, MD
Lowering LDL cholesterol
What appears to lower LDL cholesterol? Pecans (raw & organic), hibiscus tea, rice brain oil, organic extra virgin olive oil (from one country, not a mix), cordyceps mushroom, glucomannon, celery, organo oil, ginger, olive leaf, probiotics.
A Monounsaturated Fatty Acid–Rich Pecan-Enriched Diet Favorably Alters the Serum Lipid Profile of Healthy Men and Women1
Sujatha Rajaram, Kenneth Burke*, Bertrum Connell*, Tun Myint, and Joan Sabaté
- Nutr. September 1, 2001
vol. 131 no. 9 2275-2279
http://www.ilovepecans.org/nutrition-in-a-nutshell/
Nuts
Tree nuts appear to lower heart disease and atrial fibrillation.
Heart 4/16/18
Blood sugar and heart disease
Fasting blood sugar levels should be below 79mg/dl as people over 100 have a 300% higher risk of heart disease.
Fasting insulin levels should be normal to low.
Iron and heart disease
Iron is an oxidant that speeds aging and should be low or borderline low. Excess iron above 80ng/ml is dangerous for the heart. And iron increases bacterial infections (bacteria need lots of it).
http://articles.mercola.com/sites/articles/archive/2015/11/21/statin-nation-2.aspx
Statins
In studies not paid for by the drug companies making statins, statins appear not to decrease deaths over 10 years, and many of them cause diabetes- a disease that increases mortality. Statins also can cause kidney & liver damage, cataracts, cognitive and muscle problems including death from rhabdomyolysis. Lowering LDL cholesterol below 130 has not been shown to decrease mortality. Statins may lower fat soluble vitamin levels like A, E, D, K. Grapefruit may elevate statin levels in the blood.
So people taking statins appear to be in danger of getting or exacerbating diabetes. The longer the statin is taken the greater the rise in blood sugar.
Statins may cause-
diabetes
memory probs
cognitive confusion
muscle pain
neuropathy
kidney failure
liver problems (especially with antibiotic clarithromycin)
Muscle cramps
cataracts
hemhorraging
lower immune system
increase cancer
lower coQ10 & vitamin K2 necessary for heart function (and the K2 also for bone density)
increase bacterial infections
lower heme, which transports iron & oxygen to the heart
blocks glutathione that helps the heart
increases cancer
insomnia
obesity
A review of the adverse events reporting system has found that statins appear to increase neurodegenerative diseases like
Amyotrophic Lateral Sclerosis (ALS) by at least 900% (9X) & as great as 10,700% (107X) for lipophilic statins like simvastatin (Zocor) & atorvastatin (Lipitor) & lovastatin (Mevacor).
Simvastatin (Zocor) also appeared to increase motor neuron disease by 5,700% (57X).
Regular doses of lipophilic statins like simvastatin (Zocor) & atorvastatin (Lipitor) & lovastatin (Mevacor) & high doses of other statins appear to increase dementia.
acsh.org/news/2020/02/10/statins-protect-against-and-accelerate-cognitive-impairment-and-dementia-14561
The longer a statin is used, the higher the mortality.
Marc G Weisskopf, Joseph Levy, Aisha S Dickerson, Sabrina Paganoni, Maya Leventer-Roberts, Statin Medications and Amyotrophic Lateral Sclerosis Incidence and Mortality, American Journal of Epidemiology, Volume 191, Issue 7, July 2022, Pages 1248–1257, https://doi.org/10.1093/aje/kwac054
Dangers of Statin Drugs: What You Haven’t Been Told About Popular Cholesterol-Lowering Medicines
Sally Fallon and Mary G. Enig
http://www.westonaprice.org/modern-diseases/dangers-of-statin-drugs-what-you-havent-been-told-about-popular-cholesterol-lowering-medicines/
www.novamagazine.com.au/article_archive/2009/2009-12-cholesterol_lowering_drugs_statins_deception.htm
http://articles.mercola.com/sites/articles/archive/2015/11/21/statin-nation-2.aspx
Statins appear to cause more side effects than prevent heart attacks
Statins appear to reduce heart disease in 2.7% of people who take them, and cause sometimes deadly side effects in 4.4% of people who take them- liver damage, diabetes, acute kidney failure, extreme muscle weakness and cataracts.
Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database
Julia Hippisley-Cox & Carol Coupland
BMJ 2010; 340 doi: https://doi.org/10.1136/bmj.c2197 (Published 20 May 2010)
Military veterans and statin induced diabetes
In a study of over 20,000 healthy vets, taking statins more than doubled their risk of diabetes, and after getting diabetes statins increased side effects by 250%. Their risk of obesity increased by 14%.
Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults.
Mansi, I; Frei CR, Chen-Pin W, Morenson EM. Journal of General Internal Medicine, 2015; DOI: 10.1007/s11606-015-3335-1
Veterans Affairs Research Communications. “Strong statin-diabetes link seen in large study.” ScienceDaily. ScienceDaily, 7 May 2015. <www.sciencedaily.com/releases/2015/05/150507145328.htm>.
Statins and cancer
Statins may increase breast cancer, thyroid cancer in women by 40%.
Clin Endocrinol (Oxf). 2014 Jul 30. doi: 10.1111/cen.12570.
Statin use and thyroid cancer: a population-based case-control study.
Hung SH1, Lin HC, Chung SD.
Statins and diabetes
Atorvastatin (Lipitor) may increase diabetes in the short term by 22%, simvastatin (Zocor) 10%, rosuvastatin (Crestor) 18%, more with higher doses. Statins may increase diabetes by 87% in the longer term.
The mediterranean diet is three times more effective in eliminating heart disease than statins.
Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults.
Mansi I1, Frei CR, Wang CP, Mortensen EM.
J Gen Intern Med. 2015 Apr 28. [Epub ahead of print]
http://www.bmj.com/press-releases/2013/05/23/statin-use-linked-increased-risk-developing-diabetes-warn-researchers
Risk of incident diabetes among patients treated with statins: population based study BMJ 2013;346:f2610
Differential metabolic effects of distinct statins.
Koh KK, Sakuma I, Quon MJ.
Atherosclerosis. 2011 Mar;215(1):1-8. doi: 10.1016/j.atherosclerosis.2010.10.036. Epub 2010 Nov 2.
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.
Preiss D, Seshasai SR, Welsh P, Murphy SA, Ho JE, Waters DD, DeMicco DA, Barter P, Cannon CP, Sabatine MS, Braunwald E, Kastelein JJ, de Lemos JA, Blazing MA, Pedersen TR, Tikkanen MJ, Sattar N, Ray KK.
2011 Jun 22;305(24):2556-64. doi: 10.1001/jama.2011.860.
If you got diabetes after you started one of these three statins, or liver, muscle, and/or kidney damage after starting any statin, you may have a legal case against the statin maker.
http://www.nolo.com/legal-encyclopedia/crestor-lipitor-other-cholesterol-drugs-29538.html
In a study of over 150,000 women, statin usage increase diabetes for postmenopausal women by 70%.
Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women’s Health Initiative.
- L. Culver, I. S. Ockene, R. Balasubramanian, B. C. Olendzki, D. M. Sepavich, J. Wactawski-Wende, J. E. Manson, Y. Qiao, S. Liu, P. A. Merriam, C. Rahilly-Tierny, F. Thomas, J. S. Berger, J. K. Ockene, J. D. Curb, Y. Ma.
Archives of Internal Medicine, 2012; DOI: 10.1001/archinternmed.2011.625
Statins can give healthy people diabetes & obesity
A major study only using only healthy people found that statins increase diabetes in people who are healthy by 87%, and increase diabetes complications as well. The higher the dose, the higher the diabetes. Stains also increase obesity by 14% in these previously healthy people.
Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults.
Mansi I, Frei CR, Wang CP, Mortensen EM.
J Gen Intern Med. 2015 Apr 28.
Pravastatin (Pravacol) may mildly increase cancer in people who are older.
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
James Shepherd et al.
The Lancet Volume 360, No. 9346, p1623–1630, 23 November 2002
Does pravastatin promote cancer in elderly patients? A meta-analysis
Stefanos Bonovas, Nikolaos M. Sitaras
CMAJ February 27, 2007 vol. 176 no. 5 doi: 10.1503/cmaj.060803
Prospective Study of Pravastatin in the Prospective Study of Pravastatin in the
Elderly at Risk (PROSPER)
Shepherd J et al.
Lancet 2002;360:1623–1630
Red yeast rice
Red yeast rice is where statins came from (it has lovastatin) and lowers cholesterol well but also lowers coQ10, which must be supplemented (coQ10 or ubiquinol) or muscles feel weak & tired (including the heart). Statins get their benefits not from lowering cholesterol but from their anti-inflammatory effects. Because turmeric, astaxanthin, & ginger are safer major anti-inflammatories, red yeast rice should not be taken unless coQ10 and vitamin K2 are supplemented.
Ezetimibe (Zetia)
Ezetimibe (Zetia) impairs the absorption of cholesterol from the gut. While it lowers LDL cholesterol, it also can cause muscle and liver problems, lower COq10, and worsen symptoms when taken with a statin. It hasn’t been shown to reduce mortality or even heart disease.
Kastelein JJ, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. NEJM 2008;358(14):1431-43
Rossebø AB, et al. Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis. NEJM 2008;359(13):1343-56
West AM, et al. The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline. Atherosclerosis. 2011 Apr 16
http://www.drbriffa.com/2011/06/10/cholesterol-reducing-drug-ezetimibe-appears-to-do-more-harm-than-good
Peppers
Hot peppers may reduce heart attacks, strokes, & overall mortality by 13%. They need to be avoided in people with autoimmune diseases (except for black pepper).
Chopan M, Littenberg B (2017) The Association of Hot Red Chili Pepper Consumption and Mortality: A Large Population-Based Cohort Study. PLoS ONE 12(1): e0169876. doi:10.1371/journal.pone.0169876
Hibiscus tea
Hibiscus sabdariffa tea appears to lower blood pressure, LDL cholesterol, blood sugar, obesity, metabolic syndrome, & fatty liver disease and raises HDL cholesterol
Hibiscus may be very effective in lowering blood pressure in multiple studies, sometimes better than prescription blood pressure drugs.
Effect of Hibiscus sabdariffaon blood pressure and electrolyte profile of mild to moderate hypertensive Nigerians: A comparative study with hydrochlorothiazide
DC Nwachukwu et al.
Nigerian Journal of Clinical Practice 2015,Volume 18, Issue 6, Page 762-770
Mozaffari-Khosravi H, Jalali-Khanabadi B, Afkhami-Ardekani M, et al. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Human Hypertension. 2009;23:48-54.
J Altern Complement Med. 2009 Aug;15(8):899-903. doi: 10.1089/acm.2008.0540.
Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes.
Mozaffari-Khosravi H1, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F.
Herrera-Arellano A, Miranda-Sanchez J, Avila-Castro P, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, Lisinopril-controlled clinical trial. Planta Med. 2007;73:6-12.
Ngamjarus c, Pattanittum P, Somboonporn C. Roselle for hypertension in adults. Cochrane Database Syst Rev. 2010;Jan 20(1):CD007894.
Herra-Arellano A, Flores-Romero S, Chavez-Soto M, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and
randomized clinical trial. Phytomedicine 2004;11:375-382.
Kuriyan R, Kumar D, Rajendran R, Kurpad A. An evaluation of the hypolipidemic effect of an extract of
Hibiscus sabdariffa leaves in hyperlipdemic Indians: a double blind, placebo controlled trial. BMC Compl and Alt
Med 2010;10:27
Mozaffari-Khosravi H, Jalali-Khanabadi B, Afkhami-Ardehani M, Fatehi F. . J Altern and Comp Med 2009;15(8):899-903.
Triglycerides- prescription drugs
Triglyceride levels in the blood can be more important than overall cholesterol in causing heart attacks. Lowering triglycerides can significantly lower heart disease deaths. The important ratio appears to be related to HDL cholesterol, which cleans arteries of plaque. The key is having a triglyceride number that is less than double that of HDL number. So if HDL is 50, then triglycerides should be no higher than 100.
Avoid confusing triglyceride levels in the blood with the medium chain triglycerides in organic coconut oil. Medium chain triglycerides are a type of saturated fat that is easier to burn as energy than store as fat, just the opposite of other fats. So instead of making people sleepy, they give people energy to exercise and are used by weightlifters & runners before exercise. Medium chain triglycerides help stop heart disease in part because they increase energy for exercise. For people who don’t like the taste of coconut oil, MCT oil that is tasteless can be bought at health food or exerise supplement stores.
The foods that raise triglycerides the most are foods that have high fructose corny syrup, sugar, and/or flour. Any caloric drinks will increase triglycerides, especially alcohol, except dark grape juice. Dark grape juice has resveratrol, which lowers diabetes & heart disease which negates the negative effects of the sugar in the grape juice (also applies to dark raisons). Red wine vinegar taken with or before a meal combats diabetes and heart disease even better because it has resveratrol and has no calories.
Fibrates
Fibrates lower triglycerides & may increase HDL levels, but can cause muscle, kidney (up to 10% of people who take them), & liver damage (especially in combination with statins) as well as increased gallstones & reduced blood levels of COq10 & vitamin E, both essential for health. Fibrates may cause abnormal heart rhythms. In addition to their disabling side effects fibrates do not appear to decrease mortality in people with high cholesterol.
gemfibrozil (Lopid)
fenofibrate (Tricor)
clofibrate (Atomid-S)
http://www.medicinenet.com/fibrates/article.htm
https://en.wikipedia.org/wiki/Fenofibrate#Contraindications
Triglyceride- supplements
Lowering triglycerides in order of effectiveness & increasing longevity:
Exercise right after every meal (eat the carbs at the end for energy)
R lipoic acid 600mg (or 120mg alpha lipoic acid) after 2 or more meals a day
Berberine
Spirulina with a vegetable
Northern bean extract
Saunas/steamrooms/whilrpools
Glucomannan
Vitamin K2
Vitamin D3
Organic extra virgin olive oil from one country
Organic freshly/frozen ground flaxseeds with meal
Magnesium
Vitamin B complex high dosage
Garlic & onions & leeek
Mulberry leaf extract
Coffee
Cordyceps mushroom
Hawthorn berry
Coenzyme Q/CoQ10
L-carnitine
L-arginine
Taurine
D-ribose
Betaine
Peritoneal dialysis vs hemodialysis
Pecans (raw & organic)
Celery & celery seed
ginger
olive leaf
probiotics mix
Hibiscus tea
Peppers
Olive leaf
Ginger
Fenugreek
Turmeric
Milk thistle
Niacin & triglycerides
Niacin (vitamin B3) raises HDL & lowers triglycerides very well & lowers vLDL cholesterol but may increase strokes & liver problems in high doses. Taking a low dose aspirin 30 minutes before as well as using extended release niacin (Niaspan) either taken after a meal or before bed may cause less flushing or headache, which also may diminish in time. It is contraindicated in people with liver problems or gout. Inositol hexanicotinate and niacinamide don’t decrease triglycerides.
Spirulina, the source of EPA & DHA in fish oil
Spirulina is the source of EPA & DHA in fish that eat it. Spirulina may need to be taken with a vegetable in order to get the benefits. Supplementation has been shown to reduce heart attacks by 25%, and all cause mortality by 45% and improves mood/reduces depression and improves concentration & memory. EPA/DHA also appears to reduce triglycerides by 25-50% within one month.
Lancet. 1999 Aug 7;354(9177):447-55.
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico.
Biochim Biophys Acta. 2012 May;1821(5):843-51. doi: 10.1016/j.bbalip.2011.10.011. Epub 2011 Oct 25.
Fish oil — how does it reduce plasma triglycerides?
Shearer GC, Savinova OV, Harris WS.
Tumeric (curcumin) and the heart
Turmeric with a little black pepper in studies helps lower endothelial dysfunction, lowers bad cholesterol, triglycerides, oxidative plaque formation, heart failure, reperfusion injury, inflammation, heart disease, and heart attacks.
“Your Health” television program with Dr. Richard Becker and Cindy Becker 12/30/16
Blood clots, strokes, and turmeric (curcumin)
Turmeric is a spice that needs a little black pepper (3mg pepper per 1000mg turmeric) to unlock the curcumin inside. Piperine in black pepper improves the availability of the curcumin in the turmeric by 20 times. Curcumin extracts are available as well in capsule form. Liposomal curcumin appears to be the most effective (against cancer, at least).
Tumeric (in curcuma oil form) was four times more effective in preventing thrombosis (blood clots) as aspirin or warfarin (Coumadin) in one study on mice. Turmeric caused only 1/4 of the bleeding as aspirin in equivalent doses for preventing blood clots (thrombosis), making turmeric four times better than aspirin for thrombosis, inflammation, and pain. Turmeric works to reduce adenosine diphosphate (ADP), collagen and thrombin-induced platelet aggregation. Turmeric had no effect on coagulation parameters (thrombin time, prothrombin time, and activated partial thromboplastin time), which may explain why it only causes 1/4th the bleeding of aspirin at equivalent effective levels. Since aspirin & warfarin & the newer blood thinners appear equivalent in the amount of bleeding/hemorrhaging they cause at doses equivalent for preventing blood clots, turmeric appears far superior than aspirin, warfarin or the other anticoagulents in preventing clots without causing hemhorrage.
Turmeric appears to prevent ischemic strokes when given preemptively and prevent damage/speed recovery when given after a stroke.
Turmeric & painkilling
Unlike all but aspirin turmeric also is a cox2 anti-inflammatory that significantly reduces pain & inflammation & speeds healing by reducing inflammation which suppresses stem cell repair of tissue. So anyone taking blood thinners other than aspirin or turmeric are getting no extra pain relief, making turmeric & aspirin likely far better for most than the other anticoagulants. And since tumeric appears to cause 75% less bleeding than aspirin at equivalent effective doses, turmeric may be four times more effective against pain than aspirin in safe doses.
Medical College of Georgia. “Indian Spice In Turmeric Reduces Size Of Hemorrhagic Stroke.” ScienceDaily. ScienceDaily, 23 September 2008. <www.sciencedaily.com/releases/2008/09/080922135229.htm>.
Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis.
Prakash P, Misra A, Surin WR, Jain M, Bhatta RS, Pal R, Raj K, Barthwal MK, Dikshit M.
Thromb Res. 2011 Feb;127(2):111-8. doi: 10.1016/j.thromres.2010.11.007. Epub 2010 Dec 8.
Anticoagulant activities of curcumin and its derivative.
Kim DC1, Ku SK, Bae JS.
BMB Rep. 2012 Apr;45(4):221-6.
Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective
Paul A Lapchak
Expert Opinion on Investigational Drugs Volume 20, Issue 1, 2011 pages 13-221
DOI: 10.1517/13543784.2011.542410
Inhibitory effect of various Thai natural plants ethanolic extracts on platelet aggregation and blood coagulation in vitro
Suwit Duangmano, Surangkana Wonkngam, Ponghathai Ladchantha, Warissara Palanan, Ornkamon Wongtagan
Bulletin of Chaingmai Associated Medical Sciences Vol 49, No 1
Curcuminoids Limit Neutrophil-Mediated Reperfusion Injury in Experimental Stroke by Targeting the Endothelium
Janet L. Funk et al.
Microcirculation Volume 20, Issue 6, pages 544–554, August 2013
DOI: 10.1111/micc.12054
- Thiyagarajan M, Sharma SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci.74(8), 969–985 (2004)
TURMERIC PROTECTS THE BRAIN AFTER STROKE BY BLOCKING INTRAVASCULAR INFLAMMATION
Ritter, Leslie S
http://hdl.handle.net/10755/157340
Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model
Preeti Dohare et al.
BMC Complementary and Alternative Medicine20088:55
DOI: 10.1186/1472-6882-8-55
Jiang J, Wang W, Sun YJ, Hu M, Li F, Zhu DY. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood–brain barrier damage. Eur. J. Pharmacol.561(1–3), 54–62 (2007).
Tsz-Shan Kam, Cho-Yee Wong, Pui-Long Kwan, Wing Fat-Yiu, Sin-Ming Chiu, Shun-Wan Chan, Kit-San Yuen, and Robbie Chan. Journal of Medicinal Food. January 2012, 15(2): 190-199. doi:10.1089/jmf.2011.1625.
Martin, Wayne. “Curcumin (turmeric) to prevent blood clots.” Townsend Letter for Doctors and Patients Apr. 2004: 115. Academic OneFile. Web. 20 Feb. 2016
Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prost Leuk Essential Fatty Acids. 1995;52:223–227
Turmeric improves post-prandial working memory in pre-diabetes independent of insulin
Asia Pacific Journal of Clinical Nutrition
Volume 23 Issue 4 (Dec 2014)
Lee, Meei-Shyuan et al.
Curry Consumption and Cognitive Function in the Elderly
Tze-Pin Ng et al.
Am. J. Epidemiol. (1 November 2006) 164 (9): 898-906. doi: 10.1093/aje/kwj267
http://www.medwirenews.com/62/90999/Thrombosis/Turmeric_extract_shows_antiplatelet_activity.html
http://www.sciencedirect.com/science/article/pii/S0006295299002063
http://www.sciencedirect.com/science/article/pii/S0049384810006031
http://draxe.com/turmeric-benefits/
Rice bran oil & cholesterol
Rice bran oil lowers LDL cholesterol far greater on average than the statins, & doesn’t cause the diabetes, cognitive confusion, and muscle pain like statins do.
Minhajuddin M1, Beg ZH, Iqbal J. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem Toxicol. 2005 May;43(5):747-53.
http://www.ncbi.nlm.nih.gov/pubmed/15640461
Most MM1, Tulley R, Morales S, Lefevre M. Rice bran oil, not fiber, lowers cholesterol in humans. Am J Clin Nutr. 2005 Jan;81(1):64-8
Orthoefer, F. T. 2005. Rice Bran Oil. Bailey’s Industrial Oil and Fat Products. 2:10.
Blood pressure
Measuring blood pressure
People should take their blood pressure at the same time each day, multiple times. Blood pressure variability (when measured at the doctor’s office) is significantly associated with increased cardiovascular disease & mortality.
Visit-to-Visit Variability of Blood Pressure and Coronary Heart Disease, Stroke, Heart Failure, and Mortality: A Cohort Study ONLINE FIRST
Paul Muntner et al.
Ann Intern Med. Published online 28 July 2015 doi:10.7326/M14-2803
When to take blood pressure medicine
Taking blood pressure medicine before bedtime results in better blood pressure control and reduces development of diabetes by 57% in one study of 2000 patients for six months that took ACE inhibitors, ARBs, and/or beta blockers.
This makes sense in the context that for people who have had a heart attack, taking one half (40mg) of a baby aspirin before bed & the other half upon wakening may reduce future heart attacks by 75%, whereas taking the whole baby aspirin in the morning only reduces heart attacks by 50%. Treating the body at night appears to be as important as during the daytime. Splitting up the dose also reduces the chances of bleeding to near zero.
Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial
Ramón C. Hermida & Diana E. Ayala & Artemio Mojón & José R. Fernández
Diabetologia 2016 Feb;59(2):255-65
DOI 10.1007/s00125-015-3749-7
Olive leaf
Olive leaf appears to lower blood pressure by up to 12pts systolic and 5 pts diastolic over eight weeks when taken at 500mg 2X/day, equal to a prescription ACE inhibitor. Olive leaf also lowered triglycerides by 8%, and LDL cholesterol by 3%.
http://www.lifeextensionretail.com/MagazineArticleDetail.aspx?article=119009
Khayyal MT, El-Ghazaly MA, Abdall DM, Okpanyi SN, Kreuter MH. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung. 2002;52(11):797-802.
Perrinjaquet-Moccetti1 T, Busjahn A, Schmidlin C, Schmidt A, Brad B, Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother. Res.2008;22:1239-42.
Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with Captopril
Endang Susalita et al.
Phytomedicine
Volume 18, Issue 4, 15 February 2011, Pages 251–258
Cherif S, Rahal N, Haouala M, et al. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension. J Pharm Belg. 1996 Mar-Apr;51(2):69-71.
Perrinjaquet-Moccetti1 T, Busjahn A, Schmidlin C, Schmidt A, Brad B, Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother. Res.2008;22:1239-42.
Olive leaf has 31 phenos and reduces fever, kills all viruses tested (rotovirus, AIDS, etc), antibiotic-salmonella, mycoplasma, MRSA, sinusitus, psoriasis, is an antifungal/antiyeast, antimalarial, increases immune response, lowers autoimmmune overresponse, stops new blood to tumors/kills cancer cells, increases wound contraction by 85%/wound tensile strength by 35%, speeds healing of cartilage, anti-inflammatory, lowers high blood pressure, prevents diabetes/lowers blood sugar, lead chelator, lowers uric acid in gout, has vitamin E, prevents heart disease, lowers cholesterol, 1000mg daily lowers blood pressure 13pts, prevents damage from chemotherapy, prevents seizures from scabies, prevents fatty liver, helps menopausal symptoms, helps pain/stops opiate tolerance & addiction, is safe for infants
(Dr. Richard Becker, Your Health)
Strophanthus (Ouabain)
Strophanthus is a plant (Ouabain is the extract) that has been used for people experiencing high blood pressure, heart disease, angina, and heart attacks for decades. It is currently being used by a number of European (& German) cardiac clinics and hospitals because it appears to be over 80% effective in stopping angina symptoms and 85% effective in stopping and reducing the progression & damage of myocardial infarction (MI). Strophanthus may also reduce high blood pressure and thin the blood as well as aspirin without increasing bleeding.
Strophanthus extract was apparently mistakenly considered to have too much absorption variability when taken orally. It has now been demostrated that taken sublingually it appears to reduce angina & MI symptoms within minutes consistently. People taking it daily usually start by using a drop at a time under the toungue without swallowing for five minutes when using it to treat high blood pressure or angina.
Strophanthus use was also inhibited by confusion about its relation to digitalis (both heart glycosides), a medicine limited because it inhibits (slows) the sodium pump. People assumed that strophanthus was the same, but strophanthus has the opposite effect on the sodium pump as digitalis. Strophanthus in low doses appears to stimulate the sodium pump, which may be why strophanthus is so effective. Strophanthus extract appears to help a number of the problems caused by congestive heart failure.
Because strophanthus appears to reduce angina, stop myocardial infarctions, thin the blood, and lower high blood pressure all with low side effects when used sublingually, it may be the most important single treatment for heart disease, heart damage, & heart failure.
Strophanthus extract is produced in a compound pharmacy in Germany & one in South America. Here in the US it is available from a doctor:
Thomas S. Cowan, MD
661 Chenery Street
San Francisco, CA
94131
Fax : (415) 334-1014
Front Desk: (415) 334-1010
Strophanthus hispidus attenuates the Ischemia-Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion
Rohit Gundamaraju et al.Pharmacogn Mag. 2014 Aug; 10(Suppl 3): S557–S562.
doi: 10.4103/0973-1296.139782
AGBAJE, E O; FAGEYINBO, M S. Evaluating Anti-Inflammatory activity of aqueous root extract of Strophanthus hispidus DC. (Apocynaceae). International Journal of Applied Research in Natural Products, [S.l.], v. 4, n. 4, p. 7-14, jan. 2012. ISSN 1940-6223. Available at: <http://www.ijarnp.org/index.php/ijarnp/article/view/87>. Date accessed: 16 jan. 2018.
Biol Pharm Bull. 2005 Dec;28(12):2319-22.
Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats.
Rao PR1, Kumar VK, Viswanath RK, Subbaraju GV.
Ouabain – the insulin of the heart
- Fürstenwerth
lnt J Clin Pract, November 2010, 64, 12, 1591-1594
doi: 10.1111/j.1742-1241.2010.02395.x
Effect of Strophanthus on Coronary Blood Flow and Cardiac Oxygen Consumption of Normal and Failing Human Hearts
- J. BING, F. M. MARAIST, J. F. DAMMANN, JR., A. DRAPER, JR., R. HEIMBECKER, R. DALEY, R. GERARD and P. CALAZEL
Circulation. 1950;2:513-516
doi: 10.1161/01.CIR.2.4.513
Ouabain – the possible victory over the myocardial infarction” by Rolf-Jürgen Petry
http://www.infarctcombat.org/heartnews-17.html
https://bengreenfieldfitness.com/article/supplements-articles/what-is-strophanthus/
http://support.fourfoldhealing.com/article/78-medicine-strodival
Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells
Paula F. Kinoshita, Lidia M. Yshii, Ana Maria M. Orellana, Amanda G. Paixão, Andrea R. Vasconcelos, Larissa de Sá Lima, Elisa M. Kawamoto & Cristoforo Scavone
Scientific Reports 7, Article number: 4894 (2017)
doi:10.1038/s41598-017-05075-9
Prescription blood pressure medication
Testing for plasma renin activity (PRA) and avoiding prescribing renin lowering medications like ACE inhibitors or beta blockers when renin is already low (using diurtics instead) should prevent the majority of pressor responses- an increase in blood pressure when trying to treat high blood pressure.
https://www.sciencedaily.com/releases/2010/08/100819112222.htm
Alderman et al. Pressor Responses to Antihypertensive Drug Types. American Journal of Hypertension, 2010; DOI: 10.1038/ajh.2010.114
Having uncontrolled high blood pressure when young and in middle age increases the risk of strokes and dementia when elderly. Conversely, having borderline high blood pressure when elderly decreases dementia. Normal to low blood pressure when we are young or middle age is very healthy for longevity & avoiding dementia, and then is safe when we are older. Too low of blood pressure when elderly in people who have had high blood pressure most of their lives can cause dementia symptoms, and too high can increase heart attacks, strokes, & dementia.
Low blood pressure and dementia in elderly people: the Kungsholmen project
Zhenchao Guo, Matti Viitanen, Laura Fratiglioni, Bengt Winblad
BMJ 1996; 312 doi: http://dx.doi.org/10.1136/bmj.312.7034.805
http://www.webmd.com/alzheimers/news/20140714/high-blood-pressure-may-protect-the-very-old-from-dementia
Starting blood pressure drugs & fall risk
Older adults in one study had a 36% higher risk of serious falls within 15 days of starting a new blood pressure drug, and a 13-16% higher risk if increasing dosage or adding another blood pressure drug.
Short-Term Risk of Serious Fall Injuries in Older Adults Initiating and Intensifying Treatment With Antihypertensive Medication
Daichi Shimbo, C. Barrett Bowling, Emily B. Levitan, Luqin Deng, John J. Sim, Lei Huang, Kristi Reynolds and Paul Muntner
http://dx.doi.org/10.1161/CIRCOUTCOMES.115.002524
Circulation: Cardiovascular Quality and Outcomes. 2016;CIRCOUTCOMES.115.002524
Prescription blood pressure drugs
Angiotensin-converting enzyme (ACE) inhibitors
ACE inhibitors, which come from pit viper venom, are effective in increasing longevity & lowering blood pressure, especially in people who also have diabetes, heart failure, or kidney disease. They can lower zinc levels so levels should be checked and supplemented. ACE inhibitors can increase the effects of anaphylactic shock, so people with severe allergies should carry an Epi pen. Over time they may increase potassium, so levels should be checked.
Centrally active ACE inhibitors reduce cognitive decline by 50%.
fosinopril Monopril
ramipril Altace
trandolapril Mavik
perindopril Aceon
Captopril (Capoten) is a weak anticholinergic, which causes symptoms that mimic dementia and increases mortality, especially in higher doses or when taken with another anticholinergic. Lisinopril (Zestril) increases sun sensitivity & lip (and possibly skin) cancer.
Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis.
Cheng J et al.
JAMA Intern Med. 2014 May;174(5):773-85. doi: 10.1001/jamainternmed.2014.348.
http://www.medscape.com/viewarticle/556014
Noncentrally active ACE inhibitors can increase dementia 20%.
benaza Lotensin
enala Vasotec
quina Accupril
Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study.
Sink KM et al.
Arch Intern Med. 2009 Jul 13;169(13):1195-202. doi: 10.1001/archinternmed.2009.175.
Beta blockers
Beta blockers block epinephrine & norepinephrine to lower blood pressure & pulse, reduce mortality & hospitalizations. They may affect women more than men, especially during exercise. Beta blockers may lower coQ10, essential for heart energy levels.
Beta blocker don’t appear to reduce mortality in stable coronary artery disease.
β-Blockers, Calcium Antagonists, and Mortality in Stable Coronary Artery Disease: An International Cohort Study. Eur Heart J 2018;Dec 27:[Epub ahead of print].
Beta blockers and neurological effects
Lipophilic beta blockers have higher concentrations in the brain, & cause much more frequent side effects like depression, nightmares, & hallucinations. Metoprolol is also anticholinergic, which causes symptoms that mimic dementia and increases mortality, especially in higher doses or when taken with another anticholinergic. Propranolol can help with some tremors.
Liphilic beta blockers:
metoprolol
propranolol
pindolol
Central nervous system side-effects with hydrophilic and lipophilic beta-blockers.
Westerlund A.
Eur J Clin Pharmacol. 1985;28 Suppl:73-6.
Beta-blockers and central nervous system side effects.
McAinsh J1, Cruickshank JM.
Pharmacol Ther. 1990;46(2):163-97.
Cruickshank JM (2010). “Beta-blockers and heart failure”. Indian Heart J 62 (2): 101–10. PMID 21180298.
Diabetes
Non-selective β1/β2 beta blockers were the first beta blockers created. Drug companies stopped making more types of them because they can cause & exacerbate diabetes, asthma, & COPD. Most doctors stopped prescribing them.
Non-selective β1/β2 beta blockers:
carteolol
carvedilol (Coreg) may also cause impotence
labetalol (Normodyne, Trandate)
nadolol (Corgard)
penbutolol (Levatol)
pindolol (Visken)
propranolol (Hemangeol, Inderal XL, InnoPran XL)
sotalol (Betapace, Sorine, Betapace AF)
timolol (Timoptic, Betimol, Timoptic-xe)
Drug companies then started coming up with β1-selective beta blockers. β1-selective beta blockers don’t appear to cause diabetes at lower doses, but can cause or exacerbate diabetes at higher doses. So doctors usually prescribe the lower doses & add a different type of blood pressure medicine as needed.
The safest beta blockers may be the β1-selective ones below at lower doses.
nebivolol (Bystolic)- may improve sexual function, has less AEs & a stable HR & good endothelial t‐PA release
bisoprolol (Zebeta)
esmolol (Brevibloc)
acebutolol (Sectral)- may reduce sexual function
betaxolol (Kerlone, Betoptic)-may reduce sexual function
Metoprolol (Lopressor, Toprol) is β1-selective but can cause depression, nightmares, & hallucinations and along with atenolol (Tenormin) is anticholinergic, which causes symptoms that mimic dementia and increases mortality, especially in higher doses or when taken with another anticholinergic.
Even β1-selective beta blockers can block/mask the tachycardia that warns people with diabetes that their insulin has induced hypoglycemia, which is another danger.
Liu J-Y, Guo L-N, Peng W-Z, et al. Efficacy and safety of nebivolol in hypertensive patients: a meta-analysis of randomized controlled trials. Journal of International Medical Research. 2020;48(10). doi:10.1177/0300060520931625
Weiss R. Nebivolol: a novel beta-blocker with nitric oxide-induced vasodilatation. Vasc Health Risk Manag. 2006;2(3):303-8. doi: 10.2147/vhrm.2006.2.3.303. PMID: 17326335; PMCID: PMC1993984.
cvpharmacology.com/cardioinhibitory/beta-blockers
Dementia
Beta blockers can prevent dementia in people with high blood pressure but exacerbate cognitive problems in people who already have dementia.
White L, et al “Beta blocker treatment of hypertensive older persons ameliorates the brain lesions of dementia measured at autopsy: the Honolulu-Asia Aging Study” AAN 2013.
The influence of beta-blockers on delayed memory function in people with cognitive impairment.
Gliebus G1, Lippa CF.
Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):57-61.
Diuretics
Diuretics decrease sodium & water to reduce blood pressure and have the best and longest track record for decreasing mortality. They lower BP, heart attack & stroke, but deplete vitamins from the body and can trigger diabetes. Whenever taking vitamins, especially multivitains, since half are fat soluble they stay a lot longer in the body if taken with a meal or with vegetable oil.
Diuretics are best if edema (swelling caused by excess fluid) or low renin is present.
Side effects are:
Increased urination
Low sodium in your blood (hyponatremia)
Dizziness
Headaches
Increased thirst
Muscle cramps
Increased blood sugar
Increased cholesterol
Rash
Joint disorders (gout)
Impotence
Menstrual irregularities
Breast enlargement in men (gynecomastia)
mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/diuretics/art-20048129?pg=2
Thiazide diuretics
Thiazide diuretics lower blood pressure and decrease potassium in the blood. They can cause diabetes possibly as a result of lowering potassium, but still decrease overall mortality. Eating foods with and/or taking supplemental potassium is recommended. When taking a thiazide diuretic, sodium blood levels must be prevented from getting so low as to cause neurologic damage or death. Thiazide diuretics may increase uric acid and gout and may increase kidney cancer 55%. It is best to keep to a lower dose to minimize side effects, as higher doses don’t usually lower blood pressure much better but do increase side effects. Indapamide (Lozol) may be the safest thiazide diuretic, avoiding some of the effects on potassium & uric acid & apparently not causing diabetes like the other thiazide diuretics.
Doesn’t appear to increase diabetes & gout:
Indapamide (Lozol)
Appears to increase diabetes & gout:
chlorothiazide (Diuril)
chlorthalidone (Hygroton)
methyclothiazide (Enduron)
metolazone (Zaroxolyn, Diulo, Mykrox)
hydrochlorothiazide (Hydrodiuril, Microzide) also increases sun sensitivity & lip (and possibly skin) cancer, reduces coQ10
Effects of a Fixed Combination of Perindopril and Indapamide in Patients with Type 2 Diabetes and Chronic Kidney Disease
Hiddo J. Lambers Heerspink; Toshiharu Ninomiya; Vlado Perkovic; Mark Woodward; Sophia Zoungas; Alan Cass; Mark Cooper; Diederick E. Grobbee; Giuseppe Mancia; Carl Eric Mogensen; Bruce Neal; John Chalmers
Disclosures
Eur Heart J. 2010;31(23):2888-2896.
Expert Rev Cardiovasc Ther. 2006 May;4(3):319-33.
Perindopril/indapamide combination in the first-line treatment of hypertension and end-organ protection.
Gosse P.
Expert Opin Pharmacother. 2012 Jul;13(10):1515-26. doi: 10.1517/14656566.2012.698611.
Position of indapamide, a diuretic with vasorelaxant activities, in antihypertensive therapy.
Waeber B, Rotaru C, Feihl F.
Effect of indapamide SR in the treatment of hypertensive patients with type 2 diabetes.
Kuo SW, Pei-Dee, Hung YJ, Hsieh AT, Wu LY, Hsieh CH, He CT, Yang TC, Lian WC.
Am J Hypertens. 2003 Aug;16(8):623-8.
http://hyper.ahajournals.org/content/7/6_Pt_2/II161.full.pdf
Diuretic Treatment of Hypertension
Ehud Grossman et al.
doi: 10.2337/dc11-s246
Diabetes Care May 2011 vol. 34 no. Supplement 2 S313-S319
http://care.diabetesjournals.org/content/34/Supplement_2/S313.full
Journalwatch
Effects of Thiazide Diuretics on Glucose Metabolism
Joel M. Gore, MD reviewing Stears AJ et al. Hypertension 2012 May. Elliott WJ. Hypertension 2012 May.
May 23, 2012
http://www.jwatch.org/jc201205230000003/2012/05/23/effects-thiazide-diuretics-glucose-metabolism
Hypertension, Hypokalemia, and Thiazide-Induced Diabetes
A 3-Way Connection
Rajiv Agarwal
Hypertension 2008; 52: 1012-1013
doi: 10.1161/HYPERTENSIONAHA.108.121970
Elliott WJ, Meyer PM (2007). “Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis”. Lancet 369 (9557): 201–7. doi:10.1016/S0140-6736(07)60108-1. PMID 17240286.
Hypertension. 1985 Nov-Dec;7(6 Pt 2):II152-6.
A review of 10 years of experience with indapamide as an antihypertensive agent.
Potassium-sparing diuretics
Potassium-sparing diuretics increase potassium in the blood, especially in combination with ACE inhibitors and or NSAIDs and cause muscle weakness, fatigue, slow heart rate. They are weaker than other diuretics and often used in combination with thiazide diuretics to balance potassium. Triamterene added to a thiazide diuretic may lower blood pressure by an additional 4mmHg systolic.
triamterene (Dyrenium)
amiloride
eplerenone (Inspra)
spironolactone (Aldactone)- may work best with people of African heritage, treats hair loss in men, excessive hair growth in women, dose limited due to side effects
Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension.
Tu W
J Gen Intern Med. 2015 Jul 21. [Epub ahead of print]
http://www.rxlist.com/
Loop diuretics
Loop diuretics appear to have severe side effects. They may cause memory loss, brain damage and increase mortality by over 150%.
torsemide (Demadex)
furosemide (Lasix)
bumetanide (Bumex)
ethacrynic acid (Edecrin)
Use of Loop Diuretics is Associated with Increased Mortality in Patients with Suspected Coronary Artery Disease, but without Systolic Heart Failure or Renal Impairment: An Observational Study Using Propensity Score Matching
Hall Schartum-Hansen et al.
PLoS One. 2015; 10(6): e0124611.
Published online 2015 Jun 1. doi: 10.1371/journal.pone.0124611
PMCID: PMC4452510
The impact of loop diuretics in patients without heart failure
Circ J. 2012;76(8):1920-7. Epub 2012 May 26.
Loop diuretic use at discharge is associated with adverse outcomes in hospitalized patients with heart failure: a report from the Japanese cardiac registry of heart failure in cardiology (JCARE-CARD).
Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H
Crit Care Med. 2007 Nov;35(11):2516-24.
The efficacy of loop diuretics in acute renal failure: assessment using Bayesian evidence synthesis techniques.
Sampath S, Moran JL, Graham PL, Rockliff S, Bersten AD, Abrams KR.
http://connection.ebscohost.com/c/articles/271844/ccbs-loop-diuretics-associated-brain-damage-memory-loss
Alpha-blockers
Alpha-blockers are used in treating hypertension, but as they are generally weaker than many other categories they are usually added on to a stronger blood pressure drug. They don’t help heart failure or angina.
selective α1-adrenoceptor antagonists
prazosin
terazosin
trimazosin
doxazosin (Cardura) and
alfuzosin (Uroxatral) and
tamsulosin (Flomax) help both high blood pressure & enlarged prostate
non-selective antagonists
phentolamine
phenoxybenzamine
Side effects are dizziness, orthostatic hypotension, nasal congestion, headache, fluid retention and reflex tachycardia (especially with non-selective alpha-blockers). Edema is a problem that can be rectified by use of a diuretic in conjunction with the alpha-blocker.
Centrally acting α2-adrenoceptor agonists
Centrally acting a2-adrenoceptor agonists help to lower blood pressure, but increase fluid accumulation & edema so are usually administered with a diuretic to lower side effects. They can cause sedation, constipation, & stomach upset.
clonidine Catapres- can change pupil dilation & dry eyes
guanabenz
guanfacine
α-methyldopa
http://www.cvpharmacology.com/vasodilator/Central-acting
Angiotensin-receptor blockers (ARBs)
ARBs lower blood pressure well but slightly increase cancer and do not decrease mortality, which is the ultimate test of effectiveness. When used in combination with ACE inhibitors and/or beta blockers they increase kidney failure and mortality.
iscandesartan (Atacand) may be the safest
telmisartan Micardis
irbesartan Avapro
losartan Cozaar g
eprosartan Teveten
valsartan Diovan (60% more effective if taken before bedtime)
olmesartan Benicar taken by itself increases mortality
Controversies in Cardiovascular Medicine
Angiotensin Receptor Blockers May Increase Risk of Myocardial Infarction
Unraveling the ARB-MI Paradox
Martin H. Strauss, MD, FRCPC; Alistair S. Hall, MB ChB, PhD, FRCP(UK)
Circulation.0
2006; 114: 838-854
doi: 10.1161/CIRCULATIONAHA.105.594986
JAMA Intern Med. 2014 May;174(5):773-85. doi: 10.1001/jamainternmed.2014.348.
Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis.
Cheng J, Zhang W, Zhang X, Han F, Li X, He X, Li Q, Chen J.
Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147,020 patients from randomised trials
Sripal Bangalore et al.
BMJ 2011; 342 doi: http://dx.doi.org/10.1136/bmj.d2234
(note this study’s authors say ARBs don’t increase mortality, which means they found that ARBs don’t decrease mortality)
ARBs in combination therapy
ARBs + beta blockers + ACE inhibitors taken together increase kidney failure by 240% and increase mortality.
ARBs + ACE inhibitors taken together increases kidney failure by 200% and increases mortality.
Any increase in creatine appears to signal an increase in end-stage renal disease, myocardial infarction, heart failure, and mortality.
Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study
Morten Schmidt et al.
BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.j791
McAlister FA, et al “The safety of combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients: A population-based longitudinal analysis” CMAJ 2011; DOI: 10.1503/cmaj.101333.
Sipahi I, Debanne SM, Rowland DY, Simon DI, Fang JC. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomized controlled trials. Lancet Oncol. 2010 Jul;11(7):627-36.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004955/
Calcium channel blockers
Calcium channel blockers reduce blood pressure but increase mortality. The European Society of Hypertension-European Society of Cardiology guidelines recommend avoiding calcium channel blockers in the treatment of heart failure, as many studies show other blood pressure drug categories have better outcomes in people with heart failure.
citizen.org/article/public-citizen-publications-hrg-citizens-petition-to-require-a-warning-on-all-calcium-channel-blocking-drugs-hrg-publication-1378/
Calcium channel blockers appear to reduce all cause mortality in people of East Asian ancestry with heart disease.
Kow, Chia Siang MPharm*,†; Ramachandram, Dinesh Sangarran MSc†; Hasan, Syed Shahzad PhD‡,§. Use of Calcium Channel Blockers and the Risk of All-cause Mortality and Severe Illness in Patients With COVID-19: A Systematic Review and Meta-analysis. Journal of Cardiovascular Pharmacology 79(2):p 199-205, February 2022. | DOI: 10.1097/FJC.0000000000001144 journals.lww.com/cardiovascularpharm/Citation/2022/02000/Use_of_Calcium_Channel_Blockers_and_the_Risk_of.11.aspx
β-Blockers, Calcium Antagonists, and Mortality in Stable Coronary Artery Disease: An International Cohort Study. Eur Heart J 2018;Dec 27:[Epub ahead of print]. acc.org/latest-in-cardiology/journal-scans/2019/01/10/15/52/beta-blockers-calcium-antagonists-and-mortality
journals.lww.com/cardiovascularpharm/Citation/2022/02000/Use_of_Calcium_Channel_Blockers_and_the_Risk_of.11.aspx
Calcium channel blockers appear to increase the risk of heart attack, cancer, & gastrointestinal bleeding.
aafp.org/pubs/afp/issues/1998/0401/p1551.html
Amlodipine appears to increase peripheral edema and pulmonary edema.
Packer M, Carson P, Elkayam U, et al. Effect of Amlodipine on the Survival of Patients With Severe Chronic Heart Failure Due to a Nonischemic Cardiomyopathy. J Am Coll Cardiol HF. 2013 Aug, 1 (4) 308–314.https://doi.org/10.1016/j.jchf.2013.04.004
Amlodipine appears to improve survival in people with covid & heart disease.
Zhang, LK., Sun, Y., Zeng, H. et al. Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. Cell Discov 6, 96 (2020). https://doi.org/10.1038/s41421-020-00235-0 nature.com/articles/s41421-020-00235-0
Amlodipine (Norvasc)
Felodipine (Plendil)
Nicardipine (Cardene)
Diltiazem (Cardizem, Tiazac)
Isradipine
Nifedipine (Procardia) increases sun sensitivity & lip (and possibly skin) cancer
Nisoldipine (Sular)
Verapamil (Calan, Verelan, Covera-HS)
Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens. 2003;21:1011-1053.
medscape.com/viewarticle/494334_5
Calcium channel blockers for tremors & Parkinson’s (a mixed bag)
Calcium channel blockers have been shown to help prevent & lower mortality in people with Parkinson’s in a study, & in a couple of studies to cause or increase essential & Parkinson’s tremors.
American Journal of Epidemiology
Use of Calcium Channel Blockers and Parkinson’s Disease
Björn Pasternak; Henrik Svanström; Nete M. Nielsen; Lars Fugger; Mads Melbye; Anders Hviid
Disclosures
Am J Epidemiol. 2012;175(7):627-635.
Parkinsonism Relat Disord. 1998 Dec;4(4):211-4.
Calcium channel blocker-induced parkinsonism: clinical features and comparisons with Parkinson’s disease.
García-Ruiz PJ1, Javier Jiménez-Jiménez F, García de Yébenes J.
Eur Neurol. 1987;27(2):114-9.
Calcium channel blockers and essential tremor.
Topaktas S, Onur R, Dalkara T.
Skin cancer
These drugs can cause sun sensivity & may increase lip cancer up to 400%.
hydrochlorothiazide HCTZ (Aquazide H, HydroDIURIL and Microzide) a diuretic
nifedipine (Adalat, Nifediac, Procardia, Afeditab, Cordipin) a calcium channel blocker
lisinopril (Prinivil, Zestril and ACE inhibitor) increased lip cancer less than the other two
Antihypertensive Drugs and Lip Cancer in Non-Hispanic Whites
Gary D. Friedman, Maryam M. Asgari, E. Margaret Warton, James Chan, Laurel A. Habel
Arch Intern Med. 2012;172(16):1246-1251. doi:10.1001/archinternmed.2012.2754.
http://consumer.healthday.com/cancer-information-5/mis-cancer-news-102/blood-pressure-drugs-linked-to-lip-cancer-in-study-667408.html
Doxazosin
Doxazosin (Cardura) is less effective than diuretics in preventing congestive heart failure & cardiovascular disease. It may help benign prostatic hyperplasia and nightmares and night terrors.
https://en.wikipedia.org/wiki/Doxazosin
Surgery
Catheter based kidney denervation may reduce diastolic blood pressure up to 10pts and systolic up to 30pts on average w/radiofrequency ablation of renal nerves. The side effects can be a regression of left ventric hypertrophy (LVH), and the surgery can cause kidney damage.
Vericose veins
P11 CRH When veins are a pain by Marvin M. Lipman MD
Can progress to leg ulcers.
Horse chestnut may help swelling related to blood backflow.
Sclerotherapy may scar and close the vein.
Laser therapy
Vein ablation
Surgical excision
