To Jesus:
You can use this as an aide to your own research and share with your doctor.
You can use drugs.com or other trusted health websites to look up the latest information on prescription & herbal drugs possible side & interaction effects.
Addiction- nicotine
Cold turkey
It may be best to first attempt to quit by just stopping smoking completely. Studies show that getting off of all drugs at the same time improves abstinence from all of them. Someone trying to get off of another drug but still smoking is getting all of the ups & downs & cravings of smoking, which can increase relapse to other drugs.
Nicotine cravings
Black pepper smell
Smelling black pepper- rubbing balack pepper in oil under nose appears to reduce nicotine cravings.
MCT oil
Coconut oil & MCT oil may help cigarette cravings, as well as organic kale & maca, a nonaddictive stimulating adaptogen.
MCT oil taken 1/8th or more teaspoon with food or under tongue every four hours gives a lot of extra physical & mental energy all day long.
naturalnews.com/048234_quit_smoking_nicotine_addiction_nutrition.html
Lobellia
Lobellia is called Indian tobacco as it mildly stimulates nicotine receptors and may substitute during cravings. It also appears to significantly help asthma and COPD.
Natural tobacco
Next may be to switch to tobacco with no additives. Cigarette companies put in a lot of chemicals that are addictive, and people have to withdraw from both these addictive chemicals AND nicotine. Withdrawing from the chemicals first may help, then getting off the tobacco next.
Dangers of varenicline (Chantix)
Varenicline (Chantix) is used as a stop smoking treatment. It appears to increase violent & suicidal ideology in more people than any other drug reported to the FDA. The FDA has required a black box warning about suicide while on varenicline (Chantix), and the company’s own website warns about hostility & agitation as well as suicidality.
An independent review of the Adverse Event Reporting System record to the FDA by the Institute for Safe Medication Practices found that varenicline (Chantix) had 1800% higher reports of being suspected of causing acts of violence against others than other drugs. And that was independent of reports to the FDA of varenicline (Chantix) suspected of causing suicidal ideation/suicide attempts/completed suicides.
healthland.time.com/2011/01/07/top-ten-legal-drugs-linked-to-violence/
Prescription Drugs Associated with Reports of Violence Towards Others
Thomas J. Moore, Joseph Glenmullen, Curt D. Furberg
DOI: 10.1371/journal.pone.0015337
Cytisine (Tabex) (also helps alcohol addiction)
Cytisine, from the Golden Rain acacia plant (Cytisus laborinum L.), has been used for over 50
years for stopping smoking in eastern Europe. It increases smoking cessation by up to 300%.
It works by partially activating the same receptors in the brain that nicotine plugs into, while
blocking much of the effects of nicotine at the same time. It is far less expensive than nicotine
replacement therapy, as little as $17 for 100 tablets or strips. It can be ordered online (Ebay)
from Europe for as little as $16 (free shipping).
A review of 21 studies revealed that cytisine appears to be much more effective than varenicline
(Chantix) but with side effects equivalent to placebo. If taken with nicotine it can cause the
same side effects as nicotine overdose (but contains no nicotine). People usually take a dose
every two hours or so at first or just every time they feel a craving to smoke/chew tobacco,
eventually spacing their doses out more. Cytisine appears to lower the craving for nicotine on a
permanent basis in many, long after their last dose.
Adapting the Sinclair Method to nicotine addiction
Since cytisine works to block the nicotine receptors much like naltrexone blocks opiate
receptors, using the Sinclair method with cytisine for nicotine addiction may work the same way.
In the Sinclair method (78% success rate) people take a naltrexone tablet once a week then an
hour later drink alcohol intentionally. The naltrexone blocks much of the pleasure from the
alcohol and after 3 to 4 months the person’s no longer finds alcohol rewarding & moves on to
full abstinence or occasional alcohol use but only after ingesting naltrexone.
The Sinclair method might work for nicotine addiction by taking cytisine and then very slowly
smoking one cigarette or just a couple puffs off one (to avoid nicotine overdose side effects).
Because the cytisine would be blocking the pleasure of the nicotine, this could lead to an
extinguishment of the addictive behaviors as people would stop associating nicotine with
pleasure. Doing this once a day could might people control their smoking at other times
because they would know they would be able to smoke later in the day. After a couple weeks
people may estop smoking entirely because they find it no longer pleasurable.
Using the Sinclair method with cytisine for smoking might improve smoking cessation rates up to
the 78% that the Sinclair method has found for alcohol addiction.
Hajek, McRobbie and Myers (25 Feb 2013). “Efficacy of cytisine in helping smokers quit:
systematic review and meta-analysis”. Thorax 68 (11): 1037–42.
doi:10.1136/thoraxjnl-2012-203035. PMID 23404838.
Another review of comparable studies found cytisine to be more clinically and cost effective than
varenicline (Chantix).
Leaviss, Joanna; Sullivan, William; Ren, Shijie; Everson-Hock, Emma; Stevenson, Matt;
Stevens, John; Strong, Mark; Cantrell, Anna (2014). “What is the clinical effectiveness and
cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic
review and economic evaluation”. Health Technology Assessment 18 (33).
doi:10.3310/hta18330
Tabex appears to have all the benefits of Chantix, but none of the severe neurological &
behavioral side effects.
https://www.washingtonpost.com/business/economy/pill-promises-a-safer-cheaper-way-than-ch
antix-to-quit-smoking/2015/05/15/8ce5590c-f830-11e4-9030-b4732caefe81_story.html
http://www.cthreefoundation.org/about-the-sinclair-method.html#.WSnxDca1vv8
http://www.the-alcoholism-guide.org/sinclair-method.html
https://www.the-sinclair-method.com/
From the tabex.net website:
Contraindications:
Advanced atherosclerosis, some forms of schizophrenia, pheochromocytome, conditions
connected with severe impairment of the cardiovascular system and malignant hypertension.
Overdose:
As antidotes at overdose of the preparation Tabex one may use tranquilizers (anticonvulsive
effect) and antihypertensive drugs (decrease of the blood pressure).
Side effects:
The high doses may provoke nausea, vomiting, dizziness, tachycardia and muscle weakness.
These effects pass quickly after the dose is decreased. Side effects are lower at lower doses
and when not smoking while the medication is active.
Drug interactions:
The analeptic effect of cytisine decreases during combined therapy with antituberculosis drugs
(PASA, streptomycin, etc.).
Warnings:
The drug should be administered carefully to patients with exacerbated peptic ulcer.
Order from:
https://quitwithtabex.co.uk/?gclid=EAIaIQobChMI_c2Q8r7_4QIVwrrACh34swqzEAAYASAAEgL
uKPD_BwE
Is the only website that works for me when buying tabex.
Berberine for nicotine addiction
Berberine (as an extract) & in the Chinese herb Rhizoma Coptis Chinensis root (Huang Lian),
Oregon Grape root, and barberry root, appears to reduce nicotine’s addictive effects when taken
before nicotine ingestion and to reduce lung inflammation & the chances of oral cancer. It also
appears to reduce cocaine’s effects, and to help opiate withdrawal symptoms of anxiety &
depression.
J Pharm Pharmacol. 2007 Dec;59(12):1663-9.
Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat.
Lee B, Yang CH, Hahm DH, Lee HJ, Choe ES, Pyun KH, Shim I.
Toxicol Ind Health. 2013 May;29(4):317-24. doi: 10.1177/0748233711433933. Epub 2012 Mar 7.
Reducing the inhibitory effect of cigarette smoke on the activity of oral peroxidase by the
addition of berberine in cigarette filter.
Wu J, Ye X, Cui X, Li X, Zheng L, Chen Z.
Free Radic Biol Med. 2003 Feb 1;34(3):377-84.
Inhibition of oral peroxidase activity by cigarette smoke: in vivo and in vitro studies.
Reznick AZ, Klein I, Eiserich JP, Cross CE, Nagler RM.
Inflammation. 2013 Oct;36(5):1079-86. doi: 10.1007/s10753-013-9640-0.
Berberine attenuates cigarette smoke-induced acute lung inflammation.
Lin K, Liu S, Shen Y, Li Q.
Buproprion (Zyban, Wellbutrin)
Buproprion helps double smoking cessation rates over placebo. It’s largest side effects over
placebo are insomnia, nausea, dizziness, and constipation. It is contraindicated for people with
seizures, bipolar affective disorder, eating disorders, are pregnant or breast feeding. Bupropion
is a potent inhibitor of cytochrome p450 2D6, causing higher blood levels of drugs dependent on
p450 for metabolization.
The use of bupropion SR in cigarette smoking cessation
Scott Wilkes
Int J Chron Obstruct Pulmon Dis. 2008 Mar; 3(1): 45–53.
PMCID: PMC2528204
Bupropion and other non-nicotine pharmacotherapies
Elin Roddy
BMJ. 2004 Feb 28; 328(7438): 509–511.
doi: 10.1136/bmj.328.7438.509
PMCID: PMC351853
Clinical efficacy of bupropion in the management of smoking cessation.
Jorenby D.
Drugs. 2002;62 Suppl 2:25-35.
Nicotine replacement therapy (NRT)
NRT consists of nicotine gum, nicotine patches, and nicotine lozenges. It has an 10% after one
year and 7% after four years improvement in abstinence over placebo. Efficacy can be
increased by using patches & gum/lozenges in combination, and women appear to need more
followup to maintain cessation.
Nicotine replacement therapy for long-term smoking cessation: a meta-analysis.
Etter JF, Stapleton JA.
Tob Control. 2006 Aug;15(4):280-5.
A meta-analysis of the efficacy of over-the-counter nicotine replacement.
Hughes JR, Shiffman S, Callas P, Zhang J.
Tob Control. 2003 Mar;12(1):21-7.
Meta-Analysis of the Efficacy of Nicotine Replacement Therapy for
Smoking Cessation: Differences Between Men and Women
Antonio Cepeda-Benito, Jose T. Reynoso, and Stephen Erath
Journal of Consulting and Clinical Psychology
2004, Vol. 72, No. 4, 712–722 DOI: 10.1037/0022-006X.72.4.712
E cigarettes
E cigarettes can be useful in helping to stop the negative health effects of smoking, but only
when choosing a company that labels all their ingredients & has tested them all in an E cigarette
use for safety. Companies too often will put in dangerous or even deadly ingredients if it boosts
addiction & sales.
N-acetylcysteine (NAC) & nicotine addiction
NAC may help to reduce nicotine/cocaine/alcohol/gambling addiction & cravings, as well bipolar depression/mania symptoms, schizophrenia, respiratory disorders, liver problems, and grooming disorders-hair pulling, skin picking, and nail biting.
NAC appears to be one of the best treatments for COPD & all lung diseases including lower respiratory infections like influenza, especially in inhaled form.
NAC appears to reduce cancer in multiple stages with multiple interventions, making it highly useful in preventing/treating lung cancer in people who have lung damage from smoking.
alienherbalist.com/n-acetylcysteine-nac
Odlaug BL, Grant JE. N-acetyl cysteine in the treatment of grooming disorders. J Clin
Psychopharmacol. 2007;27:227–9. [PubMed]
Grant JE, Odlaug BL, Kim SW. N-acetylcysteine, a glutamate modulator, in the treatment of
trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry. 2009;66:756–63.
[PubMed]
Berk M, Jeavons S, Dean O, et al. Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting.
CNS Spectr. 2009;14:357–60. [PubMed]
LaRowe SD, Mardikian P, Malcolm R, et al. Safety and tolerability of N-acetylcysteine in
cocaine-dependent individuals. Am J Addict. 2006;15:105–10. [PMC free article] [PubMed]
LaRowe SD, Myrick H, Hedden S, et al. Is cocaine desire reduced by N-acetylcysteine? Am J
Psychiatry. 2007;164:1115–7. [PubMed]
Mardikian PN, LaRowe SD, Hedden S, et al. An open-label trial of N-acetylcysteine for the
treatment of cocaine dependence: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry.
2007;31:389–94. [PubMed]
Knackstedt LA, LaRowe S, Mardikian P, et al. The role of cystine-glutamate exchange in
nicotine dependence in rats and humans. Biol Psychiatry. 2009;65:841–5. [PMC free article]
[PubMed]
Van Schooten FJ, Besaratinia A, De Flora S, et al. Effects of oral administration of
N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol Biomarkers Prev.
2002;11:167–75. [PubMed]
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
Olivia Dean et al.
J Psychiatry Neurosci. 2011 Mar; 36(2): 78–86. doi: 10.1503/jpn.100057 PMCID: PMC3044191
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036554/
http://dro.deakin.edu.au/view/DU:30035461
http://www.sciencedirect.com/science/article/pii/S0006322306015101
http://www.sciencedirect.com/science/article/pii/S0165614713000023
http://journals.lww.com/behaviouralpharm/Abstract/2008/10000/Antidepressant_like_effects_of_
N_acetyl_L_cysteine.9.aspx
http://www.sciencedirect.com/science/article/pii/S0165614708001223
http://archpsyc.jamanetwork.com/article.aspx?articleid=483113
http://www.nature.com/npp/journal/v36/n4/abs/npp2010226a.html
Combination therapies
Using a combination of Tabex, bupropion, and nicotine replacement therapy appears to be more
effective in quitting than any one alone. Because Tabex is the most effective and the most long
lasting, it could be used first. Then if more is needed, bupropion is the next most effective.
Then if that’s not enough, using a nicotine replacement is next. If more is needed, the patch can
be used in combination with the gum or lozenge.
Bupropion alone or with a nicotine patch increased smoking cessation rates
Evid Based Mental Health 1999;2:74 doi:10.1136/ebmh.2.3.74
Combination therapy of varenicline with nicotine replacement therapy is better than varenicline
alone: a systematic review and meta-analysis of randomized controlled trials
Ping-Hsun Chang et al.
BMC Public Health 2015, 15:689 doi:10.1186/s12889-015-2055-0
http://www.healthline.com/health-blogs/freedom-smoking/does-it-help-add-nicotine-gum-bupropion
