Use this as aide to your own research and share with your doctor as appropriate.
Anticholinergics
The effects of anticholinergic medications appear to mimic dementia. They may reduce the ability to concentrate, and because they can cause people to make worse decisions & drive impulsively, each point appears to increase early death risk (mortality) by 26% & every 2 or 3 score to increase cognitive impairment by 46%.
Isocarboxazid (Marplan, Marplon, Enerzer) an MAOI is at least a type I anticholinergic
Larsen JK, Krogh-Nielsen L, Brøsen K (April 2016). “The Monoamine Oxidase Inhibitor Isocarboxazid is a Relevant Treatment Option in Treatment-Resistant Depression” (PDF). Health Care: Current Reviews. 4 (2).
ACB list 2011
theseniorlist.com/medication/anticholinergic-drugs/
uea.ac.uk/mac/comm/media/press/2011/June/Anticholinergics+study+drug+list
Rudolph JL, Salow MJ, Angelini MC, McGlinchey RE. The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med. 2008 Mar 10;168(5):508-13. doi: 10.1001/archinternmed.2007.106. PMID: 18332297.
Anticholinergics, esp ipratropium, can cause heart attacks in people with asthma.
worst-3 points
amitriptyline(Elavil)
amoxapine (Asendin)
atropine (Sal-Tropine)
benztropine (Cogentin)
brompheniramine (Dimetapp)
carbinoxamine (Histex/Carbihist)
chlopheniramine(Chlor-trimeton/tabs)
chlorpromazine (Thorazine)
clemastine (Tavist)
clomipramine (Anafranil)
clozapine (Clozaril)
cyproheptadine (Periactin)
darifenacin (Enablex)
desipramine (Norpramin)
dexchlorpheniramine
dicyclomine (Bentyl)
dimenhydrinate (Dramamine)
diphenhydramine (Benadryl)
doxepin (Sinequan)
fesoterodine (Toviaz)
flavoxate (Urispas)
hydroxyzine (Atarax/Vistiril)
hyoscyamine (Anaspaz/Levsin)
imipramine (Tofranil)
meclizine (Antivert)
methocarbamol (Robaxin)
nortriptyline (Pamelor)
olanzapine (Zyprexa)
orphenadrine (Norflex)
oxybutynin (Ditropan)
paroxetine (Paxil)
perphenazine (Trilafon)
promethazine (Phenergan)
propanthelin
protriptyline (Vivactil)
pseudoephedrine HCl/Triprolidine HCl (Aprodine)
quetiapine (Seroquel)
scopolamine
thioridazine (Mellaril)
tolterodine (Detrol)
trifluoperazine (Stelazine)
trihexyphenidyl (Artane)
trimipramine (Surmontil)
ACB-2 points
amantadine (Symmetrel)
belladonna
carbamazepine (Tegretol)
cyclobenzaprine (Periactin)
loxapine (Loxitane)
meperidine (Demerol)
methtrimepazine (Levoprome)
molindone (Moban)
oxcarbazepine (Trileptal)
pimozide (Orap)
ACB-1 point
alverine (Spasmonal)
alprazolam (Xanax)
atenolol (Tenormin)
baclofen
bupropion (Wellbutrin/Zyban)
captopril (Capoten)
carisoprodol (Soma)
cetirizine (Zyrtec)
chlorthalidone (Diuril/Hygroton)
cimetidine (Tagamet)
clorazepate (Tranxene)
codeine (Contin)
colchicine (Colcrys)
diazepam (Valium)
digoxin (Lanoxin)
diphenoxylate (Lomotil)
dipyridamole (Persantine)
disopyramide (Norpace)
fentanyl (Duragesic/Actiq)
fluphenazine (Prolixin)
fluvoxamine (Luvox)
furosemide (Lasix, also brain damage)
haloperidol (Haldol)
hydrochlorothiazide (Esidrix, Dyazide, HydroDIURIL, & Maxzide)
hydralazine (Apresoline)
hydrocortisone (Cortef/Cortaid)
isosorbide (Isordil/Ismo)
loperamide (Immodium)
loratidine (Alavert, Claritin)
maprotiline
metoprolol (Lopressor/Toprol)
morphine
nifedipine (Procardia/Adalat)
prednisone (Deltasone/Sterapred)
quinidine (Quinaglute)
ranitidine (Zantac)
risperidone (Risperdal)
theophylline (Theodur/Uniphyl)
thiothixene (Navane)
tizanidine (Zanaflex)
trazodone (Desyrel)
triamterene (Dyrenium)
warfarin (Coumadin)
Clonidine (Catapres) may have an anticholinergic effect.
[Anticholinergic action of clonidine on cardiovascular effects of the central cholinergic estimulation].
Taira CA
Acta Physiol Pharmacol Ther Latinoam. 1996;46(2):119-26.
http://doublecheckmd.com/EffectsDetail.do?dname=clonidine&sid=11980&eid=5692
Chest. 2010 Jan;137(1):13-9. doi: 10.1378/chest.08-2367. Epub 2009 Apr 10.
Cardiovascular events associated with ipratropium bromide in COPD.
Ogale SS, Lee TA, Au DH, Boudreau DM, Sullivan SD.
https://www.peoplespharmacy.com/articles/where-can-i-find-a-list-of-anticholinergic-drugs
American College of Chest Physicians. “Ipratropium bromide may increase risk for cardiovascular events.” ScienceDaily. ScienceDaily, 10 January 2010. <www.sciencedaily.com/releases/2010/01/100105183800.htm>.
Annals of Internal Medicine (2008) 149: 380-390
