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Liver
What may hurt:
GMO corn & soy
High fructose corn syrup (HFCS)
Allopurinol
Alcohol
What may help:
Eating organic
Spirulina w/a vegetable
Milk thistle
N-acetyl-cysteine (NAC)
Acetyl glutathione, (lecithin) liposomal glutathione, intranasal glutathione
Probiotics
Coffee
Anti-inflammatories- alpha lipoic acid, turmeric (with a little black pepper), ginger, astaxanthin, boswellia, msm, PEA, resveratrol (red grapes/vinegar, cocoa)
Liposomal vitamin C (Mercola.com)
Brassica family (kale, broccoli, etc.)
Coconut oil/mct oil
Vitamin B complex
Zinc
Huaier granule
Carnitine
Adaptogens- Astragalus, Ashwaganda
Cordyceps mushroom (also organic medicinal mushroom mix)
Ginkgo
Roobios tea
Celery
dandelion leaves, rootd
yellow dock root
burdock root
Artichoke
basil
hibiscus tea
Aspirin
Liver functioning
What causes liver damage?
GMO corn & soy
GMO corn & soy is “Roundup Ready”, which means the herbicide glyphosate can be used on the plants in excess without killing them, only the weeds (until the weeds become resistant). Glyphosate is a patented antibiotic (Patent No.: US 7771736), which may kill good bacteria in the gut, causing dysbiosis, non-alcoholic fatty liver disease (NAFLD), & non-alcoholic steatohepatosis (NASH) even at ultra low doses in rats in one study.
Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide
Robin Mesnage, George Renney, Gilles-Eric Séralini, Malcolm Ward & Michael N. Antoniou
Scientific Reports 7, Article number: 39328 (2017)
doi:10.1038/srep39328
http://articles.mercola.com/sites/articles/archive/2017/01/24/what-does-roundup-do-to-liver.aspx?utm_source=dnl&utm_medium=email&utm_content=ms1&utm_campaign=20170205Z1&et_cid=DM133142&et_rid=1872629152
Killing the good bacteria in the gut also increases diabetes, heart disease, obesity, and cancer. The World Health Organization (WHO) has judged glyphosate a probable carcinogen, the last step before naming it a definate cause of cancer.
New genetic research has found that GMO corn is substantially different from nonGMO corn, a finding that would have prevented it from being sold without extensive human testing and has caused the majority of countries around the world to ban it.
High fructose corn syrup (HFCS)
HFCS, a sweetener found in processed foods, appears to significantly increase liver damage. It is now hidden under other names for corn like dextrose & corn starch.
Allopurinol
Allopurinol for gout may damage the liver.
Green tea supplements
Taking 800mg or more of EGCG may increase liver damage risk.
EFSA Journal 4/18/18
What may help:
Organic
Eating organic is the only way to be safe, as studies are finding glyphosate in a large variety of nonorganic products as hundreds of crops are sprayed with it before harvest.
https://s3.amazonaws.com/media.fooddemocracynow.org/images/anresco_reports_food_testing_2016.pdf
http://www.ecowatch.com/monsanto-glyphosate-cheerios-2093130379.html
An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process
Robin Mesnage, Sarah Z. Agapito-Tenfen, Vinicius Vilperte, George Renney, Malcolm Ward, Gilles-Eric Séralini, Rubens O. Nodari & Michael N. Antoniou
Scientific Reports 6, Article number: 37855 (2016)
doi:10.1038/srep37855
Cytotoxicity on human cells of Cry1Ab and
Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide
R. Mesnage et al.
(wileyonlinelibrary.com) DOI 10.1002/jat.2712
Spirulina- DHA & EPA omega 3 fatty acid
Fatty liver disease is often associated with obesity, alcohol and sugar, especially high fructose corn syrup and can cause inflammation, oxidative stress, and fibrosis that can lead to liver damage and failure. Treatments are to avoid alcohol and sugar, especially high fructose corn syrup and to lose weight, all of which have been shown to halt/reduce/reverse fatty liver disease.
DHA is an omega3 fatty acid found in fish (as is EPA) that eat the algae spirulina. DHA has been shown in multiple studies on mice to prevent liver damage/hepatic steatosis (1,5,7,8,9), increase insulin sensitivity (5,8), and to significantly reduce inflammation, oxidative stress, and fibrosis in mice who had fatty liver disease (2). DHA also prevented necroinflammatory liver injury in mice (3). In human studies (adults (4) and children (6)) DHA & EPA reduced fatty liver fat (4,5) improved insulin sensitivity (6), and prevents liver damage (10) in patients with non-alcoholic fatty liver disease (NAFLD).
The importance of this is significant, as many treatments for fatty liver disease rely on weight loss to reduce or reverse the fatty liver disease. To find DHA stops the damage from fatty liver disease gives doctors a different way to help people protect themselves from further damage even if they can’t immediately lose enough weight to reverse the fatty liver disease.
DHA & EPA fatty acids have also been shown to work as strong as prescription antidepressants in improving mood, increase concentration/memory/test scores, and appear more than twice as effective against schizophrenia as prescription antipsychotics, and also help ADHD, autism, and bipolar disorder. They appear to also lower LDL, blood pressure and high triglyceride levels in the blood and reduce inflammation in arthritis.
How to take
Organic spirulina is inexpensive in both powder or wafer (tablet) form. I have found that it needs to be eaten in a meal with a vegetable in order to be fully usable. DHA is also available as a spirulina extract, and in fish oil (much more expensive).
Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, et al. (2013) A Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR-/- Mice. PLoS ONE 8(12): e83756. doi:10.1371/journal.pone.0083756
J Nutr. 2013 Mar;143(3):315-23. doi: 10.3945/jn.112.171322. Epub 2013 Jan 9.
Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.
Depner CM, Philbrick KA, Jump DB
Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA
Ana González-Périz et al.
The FASEB Journal December 2006 vol. 20 no. 14 2537-2539
doi: 10.1096/fj.06-6250fje
Hepatology. 2014 Oct;60(4):1211-21.
Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* study.
Scorletti E, Bhatia L, McCormick KG, Clough GF, Nash K, Hodson L, Moyses HE, Calder PC, Byrne CD; WELCOME Study.
Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins
Ana González-Périz et al.
doi: 10.1096/fj.08-125674
The FASEB Journal June 2009 vol. 23 no. 6 1946-1957
Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial
Valerio Nobili et al.
Arch Dis Child doi:10.1136/adc.2010.192401
ω-3 Fatty Acids Prevent Hepatic Steatosis, Independent of PPAR-α Activity, in a Murine Model of Parenteral Nutrition–Associated Liver Disease
Esther Prince, MD et al.
doi: 10.1177/0148607113491436
JPEN J Parenter Enteral Nutr July 2014 vol. 38 no. 5 608-616
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
Motohiro Sekiya et al.
Hepatology Volume 38, Issue 6 December 2003 Pages 1529–1539
Pediatric Research (2005) 57, 445–452; doi:10.1203/01.PDR.0000153672.43030.75
Omega-3 Fatty Acid Supplementation Prevents Hepatic Steatosis in a Murine Model of Nonalcoholic Fatty Liver Disease
Ian P J Alwayn et al.
P T. 2008 May; 33(5): 271–303.
PMCID: PMC2683599
Omega-3-acid Ethyl Esters (Lovaza) For Severe Hypertriglyceridemia
Renee R. Koski, PharmD, CACP
Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study
M. CAPANNI et al.
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 8, pages 1143–1151, April 2006
http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200700399/abstract
http://journals.lww.com/jcge/Abstract/2008/04000/Highly_Purified_Eicosapentaenoic_Acid_Treatment.17.aspx
Probiotics & liver
Probiotics may help people with liver failure by reducing toxic byproducts from toxic bacteria & fungi. Studies show the ones with the most types of probiotic bacteria are the most effective.
Your Health by Dr. Richard Becker and Cindy Becker
Milk thistle
Milk thistle appears to help heal & protect the liver, including against the toxic effects of chemotherapy & moderate blood sugar, lowers LDL cholesterol, and kill cancer cells, including ovarian cancer in studies.
http://www.sciencedirect.com/science/article/pii/S0959804903006245
http://online.liebertpub.com/doi/abs/10.1089/107628003322256878?journalCode=act
http://www.sciencedirect.com/science/article/pii/S0304383599002761
http://www.nature.com/ajg/journal/v93/n2/abs/ajg1998644a.html
http://online.liebertpub.com/doi/abs/10.1089/107555303765551633
Coffee
Coffee has been associated with lower liver cancer levels. A 2007 meta-analysis found an increase in consumption of two cups of coffee per day was associated with a 43 percent reduced risk of liver cancer. It also appears to slow down the progression of liver disease to cirrhosis, helps people with hepatitis C, and lowers the risk of death in people with cirrhosis.
Coffee Consumption and Risk of Liver Cancer: A Meta-Analysis
Susanna C. Larssoncorrespondenceemail, Alicja Wolk
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Received: January 26, 2007; Accepted: March 8, 2007; Published Online: March 04, 2014
Article has an altmetric score of 131
DOI: http://dx.doi.org/10.1053/j.gastro.2007.03.044
Impact of coffee on liver diseases: a systematic review
Sammy Saab et al.
DOI: 10.1111/liv.12304
Liver International Volume 34, Issue 4, pages 495–504, April 2014
Vitamin B complex and carnitine
Vitamin B complex and the amino acid carnitine may help reduce liver inflammation.
Dr. Richard Becker and Cindy Becker on “Your Health” 01/12/17
Aspirin
Aspirin usage was associated with a 37% reduction in liver cancer for people with hepatitus B in one study.
American Association for the Study of Liver Diseases (AASLD). “Can an aspirin a day keep liver cancer away?.” ScienceDaily. ScienceDaily, 20 October 2017. <www.sciencedaily.com/releases/2017/10/171020093040.htm>.
Astragalus
Astragalus appears to help tissue in the liver recover from chronic infection and the heart in myocarditis.
http://ndnr.com/autoimmuneallergy-medicine/astragalus-use-of-the-herb-in-the-treatment-of-allergy-autoimmunity/
Chen H, Weng L. Comparison on efficacy in treating liver fibrosis of chronic hepatitis B between Astragalus Polygonum anti-fibrosis decoction and jinshuibao capsule. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000;20(4):255-257.
Du X, Chen X, Zhao B, et al. Astragalus polysaccharides enhance the humoral and cellular immune responses of hepatitis B surface antigen vaccination through inhibiting the expression of transforming growth factor β and the frequency of regulatory T cells. FEMS Immunol Med Microbiol. 2011;63(2):228-235.
Zheng J, Ma LT, Ren QY, et al. The influence of astragalus polysaccharide and ß-elemene on LX-2 cell growth, apoptosis and activation. BMC Gastroenterol. 2014;14(1):1196.
Huaier granule (Poria robiniophila extract) appears to improve survival in the treatment of liver cancer.
https://www.medscape.com/viewarticle/897661
Prescription drug treatments
Immune checkpoint inhibitors and other medications & medical treatments appear to help increase survival in people with liver cancer:
lenvatinib (Lenvima)
cabozantinib (Cabometyx)
sorafenib (Nexavar)
nivolumab (Opdivo)
regorafinib (Stivarga)
Ramucirumab (Cyramza
transarterial chemoembolization (TACE)
Sorafenib (Nexavar) appears to work as well at lower dosages and with lower side effects than commonly used.
https://www.medscape.com/viewarticle/881665
https://www.medscape.com/viewarticle/879283
https://www.medscape.com/viewarticle/874803
https://www.medscape.com/viewarticle/865648
https://www.medscape.com/viewarticle/885764
https://www.medscape.com/viewarticle/898412
https://www.medscape.com/viewarticle/891597
Immunotherapy
Cytokine-induced killer T-cells appears to siginficantly improve survival in liver cancer patients.
https://www.medscape.com/viewarticle/895386
Other:
Cordyceps mushroom may help
Ginkgo may help prevent hepatitis from advancing to cancer
Roobios tea may increase cy450 production (enhancing liver function)
Liver supporting herbs (milk thistle, dandelion root, yellow dock root, burdock root, artichoke, basil)
Anti-inflammatory herbs appear to help liver recovery and stop liver damage:
Turmeric (with a little black pepper) may help stop jaundice, ginger, astaxanthin, boswellia, msm, PEA, resveratrol
kale, broccoli & other greens increase glutathione
N-acetyl-cysteine
Coconut oil/mct oil
Alpha lipoic acid
Medicinal mushroom mix (organic)
Ashwaganda
dandelion leaves, root
Liposomal vitamin C (Mercola.com)
hibiscus tea
A Promising All-Oral Regimen for HCV Infection Post–Liver Transplantation
Atif Zaman, MD, MPH Reviewing Kwo PY et al., N Engl J Med 2014 Nov 11;
A 24-week regimen of ombitasvir–ABT-450/r, dasabuvir, and ribavirin achieved sustained virologic response in 33 of 34 patients. Few serious adverse events occurred.
Susanna C. Larssoncorrespondenceemail, Alicja Wolk
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Received: January 26, 2007; Accepted: March 8, 2007; Published Online: March 04, 2014
Article has an altmetric score of 131
DOI: http://dx.doi.org/10.1053/j.gastro.2007.03.044
Surgery?
Radio frequency ablation (RFA) of a liver (or lung) tumor appears to significantly increase cancer survival vs other nonsurgical interventions, and is minimally invasive and repeatable as needed.
https://emedicine.medscape.com/article/1390475-overview?pa=QoxH3n%2F%2Fi%2FHINuRkP628sU1l%2FnZQe6hZcdHfzQ1XUjnmEyb2BMxIopFh1JBSC4kH43mU9jD%2B1DtnxY47OmyybA%3D%3D
